Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case-control study.

Autor: Onor IO; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.; Department of Pharmacy, University Medical Center New Orleans, New Orleans, LA, USA., Duchane RM; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Payne CJ; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Lambert HN; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Mitchner DM; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.; Department of Pharmacy, University Medical Center New Orleans, New Orleans, LA, USA., Beyl RA; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Nguyen AT; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Bilbe SE; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., White AA; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Johnson MW; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Faciane AI; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Kouagou E; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Hymel SA; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Wates BM; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Sanders AD; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Vo PCB; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Bates JD; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Spooner RJ; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Gillard CJ; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.; Department of Pharmacy, University Medical Center New Orleans, New Orleans, LA, USA., Okogbaa JI; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA., Sarpong DF; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.; Center for Minority Health and Health Disparities Research and Education, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA., Hadgu RM; Midwestern University College of Pharmacy - Glendale, Glendale, AZ, USA., Okpechi SC; Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences Center, Louisiana State University, New Orleans, LA, USA., Onor GI Jr; Warren Alpert Medical School, Brown University, Providence, RI, USA., Okoronkwo MC; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA., Naljayan MV; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA., Guillory SG; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA., Sanne SE; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.
Jazyk: angličtina
Zdroj: Journal of clinical hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)] 2021 Sep; Vol. 23 (9), pp. 1767-1775. Date of Electronic Publication: 2021 Jul 22.
DOI: 10.1111/jch.14268
Abstrakt: The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age-, sex-, race-, diabetes, and body mass index matched). This study is a single-center, retrospective, chart review, case-control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Patients were included in the case group if they were 18 years of age or older with hypertensive crises and have a documented calcium level. The control group patients were required to be 18 years of age or older, have a documented calcium level, and have no diagnosis of hypertensive crises. The primary outcome of the study was to compare the mean serum calcium in patients with hypertensive crises vs patients without hypertensive crises. Five hundred and sixty-six patients were included in the study: 283 patients in both the case group and control group. The primary outcome results showed that serum calcium concentration was not significantly different between the case group (8.99 ± 0.78 mg/dL) and control group (8.96 ± 0.75 mg/dL) (P = .606). This study found no significant difference in serum calcium levels in patients with hypertensive crises compared to a random matched control group. Larger observational or experimental studies may be useful to evaluate the effect of calcium on blood pressure in hypertensive crises.
(© 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: