Are young Iranian women with metabolically healthy obesity at increased risk of CVD incidence?

Autor: Hosseini SA; Ahvaz Jundishapur University of Medical Sciences, Hyperlipidemia Research Center, Ahvaz, Iran.; Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran., Aghamohammadi V; Khalkhal University of Medical Sciences, Department of Nutrition, Khalkahl, Iran., Ashtary-Larky D; Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran., Alipour M; Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran., Ghanavati M; Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran., Lamuchi-Deli N; Ahvaz Jundishapur University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Ahvaz, Iran.
Jazyk: angličtina
Zdroj: Jornal vascular brasileiro [J Vasc Bras] 2020 Sep 14; Vol. 19, pp. e20190106. Date of Electronic Publication: 2020 Sep 14 (Print Publication: 2020).
DOI: 10.1590/1677-5449.190106
Abstrakt: Background: The association between the Metabolically Healthy Obese (MHO) phenotype in the absence of metabolic syndrome and subsequent cardiovascular disease remains unclear.
Objectives: We examined the association between MHO and CVD risk in young Iranian women.
Methods: We studied 183 women aged 20-35 years from a population of 308 candidates. We classified participants into 4 phenotypes. We measured body composition, blood pressure, and biochemical factors in all participants.
Results: The Metabolically Healthy Normal Weight (MHNW) and Normal Weight Obese (NWO) phenotypes had no statistical differences in any biochemistry variables. FBS, TG, LDL/HDL, Cholesterol/HDL, hs-CRP, and atherogenic index of plasma (AIP) were all higher in Metabolically Unhealthy Obese (MUO) than MHO individuals, whereas HDL was higher in MHO than in MUO individuals. LDL/HDL and hs-CRP were higher in MHO participants than MHNW participants, whereas HDL-c was higher in MHNW than MHO.
Conclusions: Results of the present study demonstrate that young women displaying the MHO phenotype have a favorable metabolic profile as shown by lower FBS, TG, LDL-c/HDL, Cho/HDL, hs-CRP, and AIP and higher HDL levels than the MUO phenotype. However, MHO individuals were still at greater risk of CVD incidence (lower HDL and higher hs-CRP levels) than MHNW individuals.
Competing Interests: Conflicts of interest: No conflicts of interest declared concerning the publication of this article.
Databáze: MEDLINE
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