Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling.
| Autor: | Wang HH; Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.; Department of Endocrinology, Qiqihar First Hospital, Qiqihar, China.; Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, China., Ma JN; Department of Endocrinology, Qiqihar First Hospital, Qiqihar, China., Zhan XR; Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.; Department of Endocrinology, Qiqihar First Hospital, Qiqihar, China. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jul 05; Vol. 12, pp. 670031. Date of Electronic Publication: 2021 Jul 05 (Print Publication: 2021). |
| DOI: | 10.3389/fendo.2021.670031 |
| Abstrakt: | Ferroptosis is an emerging programmed cell death distinguished from apoptosis and autophagy and plays essential roles in tumorigenesis. Thyroid cancer is a prevalent endocrine tumor, but the molecular mechanism of ferroptosis during thyroid cancer development remains unclear. Here, we identified the critical function of circular RNA circ_0067934 in repressing ferroptosis of thyroid cancer cells. Our data showed that the ferroptosis activator erastin decreased thyroid cancer cell viabilities, while the circ_0067934 shRNA further attenuated erastin-inhibited cell viabilities. The silencing of circ_0067934 enhanced the levels of ferroptosis-related markers, including Fe 2+ , iron, and ROS in the cells. The knockdown of circ_0067934 induced thyroid cancer cell apoptosis and repressed thyroid cancer cell proliferation in vitro and in vivo . Circ_0067934 upregulated the expression of the ferroptosis-negative regulator SLC7A11 by sponging and inhibiting miR-545-3p in thyroid cancer cells. The overexpression of SLC7A11 or the inhibitor of miR-545-3p reversed circ_0067934 silencing-regulated thyroid cancer cell proliferation. Therefore, we concluded that Circ_0067934 attenuated ferroptosis of thyroid cancer cells by miR-545-3p/SLC7A11 signaling. Circ_0067934 may serve as a potential therapeutic target by regulating ferroptosis for the treatment of thyroid cancer. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Wang, Ma and Zhan.) |
| Databáze: | MEDLINE |
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