Association of Soy and Exclusive Breastfeeding With Central Precocious Puberty: A Case-Control Study.

Autor:	Felício JS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Alcântara AL; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Janaú LC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Moraes LV; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Oliveira MCNI; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Lemos MN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza Neto NJK; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Neto JFA; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., da Silva WM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza ÍJA; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Said NM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Lemos GN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Vieira GM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Khayat AS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Dos Santos ÂKCR; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Queiroz NNM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Sousa ACCB; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Dos Santos MC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Melo FTC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Piani PPF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Felício KM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jul 05; Vol. 12, pp. 667029. Date of Electronic Publication: 2021 Jul 05 (Print Publication: 2021).
DOI:	10.3389/fendo.2021.667029
Abstrakt:	Introduction: While soy is suggested as a possible risk factor, exclusive breastfeeding (EBF) has a likely protective effect in precocious puberty. Our aim was to evaluate the association between both of these variables with central precocious puberty (CPP). Methods: We performed a retrospective, case-control study. A total of 161 girls were divided into two groups: 84 patients diagnosed with CPP composed the case group and 77 patients without the diagnosis of CPP (had gone through normal onset of puberty) were the control group. Results: Our control group had a higher presence of EBF >6 months, which was an important protective factor for CPP (OR: 0.5; IC 95%: 0.3-0.9, p = 0.05) and also correlated negatively with the presence of it (r = -0.2; p < 0.05). Oppositely, the use of soy was significantly higher in the CPP group, (OR: 3.8; IC 95%: 1.5-6, p < 0.05) and positively correlating (r = 0.2; p < 0.01) with the presence of CPP. Duration of soy intake (years) correlated with bone age (r = 0.415; p < 0.05). A logistic regression was performed to evaluate the effects of EBF duration and soy on CPP. The model was significant (x² (2) = 20,715, p = <0.001) and explained 12.2% (Nagelkerke R2) of the variance, correctly classifying 62.5% of cases. EBF was associated with a reduction of likelihood of having CPP [OR = 0,187 (CI = 0.055-0,635); Wald = 7,222, p = 0.007], while soy intake increased the risk [OR = 3.505 (CI) = 1,688-7,279, Wald = 11,319, p = 0.001]. Conclusion: Our data found the use of soy was associated with CPP. Additionally, EBF was pointed as a protective factor. However, future prospective studies are needed to clarify this issue. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Felício, de Alcântara, Janaú, de Moraes, de Oliveira, de Lemos, de Souza Neto, Neto, da Silva, de Souza, Said, de Lemos, Vieira, Khayat, Santos, de Queiroz, de Sousa, Santos, de Melo, Piani and Felício.)
Databáze:	MEDLINE
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