Biomarkers of Inflammation and Oxidative Stress among Adult Former Smoker, Current E-Cigarette Users-Results from Wave 1 PATH Study.
| Autor: | Christensen CH; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland. carol.christensen@fda.hhs.gov., Chang JT; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Rostron BL; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Hammad HT; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., van Bemmel DM; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Del Valle-Pinero AY; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Wang B; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Mishina EV; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Faulcon LM; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., DePina A; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Brown-Baker L; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Kimmel HL; National Institute of Drug Abuse, Bethesda, Maryland., Lambert E; National Institute of Drug Abuse, Bethesda, Maryland., Blount BC; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia., Vesper HW; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia., Wang L; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia., Goniewicz ML; Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Hyland A; Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Travers MJ; Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Hatsukami DK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Niaura R; College of Global Public Health, New York University, New York, New York., Cummings KM; Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina., Taylor KA; Westat, Rockville, Maryland., Edwards KC; Westat, Rockville, Maryland., Borek N; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Ambrose BK; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland., Chang CM; Office of Science, Center for Tobacco Products, FDA, Silver Spring, Maryland. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Oct; Vol. 30 (10), pp. 1947-1955. Date of Electronic Publication: 2021 Jul 21. |
| DOI: | 10.1158/1055-9965.EPI-21-0140 |
| Abstrakt: | Background: Former smokers who currently use e-cigarettes have lower concentrations of biomarkers of tobacco toxicant exposure than current smokers. It is unclear whether tobacco toxicant exposure reductions may lead to health risk reductions. Methods: We compared inflammatory biomarkers (high-sensitivity C-reactive protein, IL6, fibrinogen, soluble intercellular adhesion molecule-1) and an oxidative stress marker (F2-isoprostane) among 3,712 adult participants in Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study by tobacco user groups: dual users of cigarettes and e-cigarettes; former smokers who currently use e-cigarettes-only; current cigarette-only smokers; former smokers who do not currently use any tobacco; and never tobacco users. We calculated geometric means (GM) and estimated adjusted GM ratios (GMR). Results: Dual users experienced greater concentration of F2-isoprostane than current cigarette-only smokers [GMR 1.09 (95% confidence interval, CI, 1.03-1.15)]. Biomarkers were similar between former smokers who currently use e-cigarettes and both former smokers who do not use any tobacco and never tobacco users, but among these groups most biomarkers were lower than those of current cigarette-only smokers. The concentration of F2-isoprostane decreased by time since smoking cessation among both exclusive e-cigarette users ( P Conclusions: Dual users have greater concentration of F2-isoprostane than smokers. Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers. Impact: This study contributes to an understanding of the health effects of e-cigarettes. (©2021 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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