Male vitamin D status and male factor infertility.

Autor:	Banks N; Department of Obstetrics and Gynecology, Virginia Commonwealth University Health, Richmond, Virginia. Electronic address: Nicole.Banks@vcuhealth.org., Sun F; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut., Krawetz SA; Department of Obstetrics and Gynecology and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan., Coward RM; Department of Urology, University of North Carolina, Chapel Hill, North Carolina., Masson P; Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania., Smith JF; Department of Urology, University of California, San Francisco, California., Trussell JC; Department of Urology, Upstate University Hospital, Syracuse, New York., Santoro N; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado., Zhang H; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut., Steiner AZ; Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 2021 Oct; Vol. 116 (4), pp. 973-979. Date of Electronic Publication: 2021 Jul 18.
DOI:	10.1016/j.fertnstert.2021.06.035
Abstrakt:	Objective: To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility. Design: Secondary analysis of a randomized, controlled trial. Setting: Nine fertility centers in the United States. Patient(s): Men (n = 154) with sperm concentration between 5 and 15 million/mL, motility ≤40%, or normal morphology ≤4% were eligible. Female partners were ovulatory, ≤40 years old, and had documented tubal patency. Intervention(s): Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels. They were randomly assigned to receive a vitamin formulation including vitamin D 2,000 IU daily or placebo for up to 6 months. Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6. Main Outcome Measure(s): Primary: sperm concentration, motility, morphology, and DNA fragmentation at baseline. Secondary: cumulative pregnancy, miscarriage, and live birth rates. Result(s): Semen parameters and sperm DNA fragmentation were not statistically significantly different between men with vitamin D deficiency and men with 25(OH)D levels ≥20 ng/mL. In addition, clinical pregnancy and live birth rates were similar. Male 25(OH)D level <20 ng/mL was associated with a higher rate of pregnancy loss (adjusted odds ratio 9.0; 95% confidence interval 1.3 to 61.3). Conclusion(s): Vitamin D deficiency in the male partner did not significantly impact semen parameters or treatment outcomes. Further study is warranted to better characterize the rate of miscarriage in couples with male vitamin D deficiency. (Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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