Single-neuron correlate of epilepsy-related cognitive deficits in visual recognition memory in right mesial temporal lobe.

Autor: Lee SJ; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FLA, USA., Beam DE; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Schjetnan AGP; Krembil Neuroscience Centre, University Health Network, Toronto, ON, Canada., Paul LK; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA., Chandravadia N; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Reed CM; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Chung JM; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ross IB; Department of Neurosurgery, Huntington Memorial Hospital, Pasadena, CA, USA., Valiante TA; Krembil Neuroscience Centre, University Health Network, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada., Mamelak AN; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Rutishauser U; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2021 Sep; Vol. 62 (9), pp. 2082-2093. Date of Electronic Publication: 2021 Jul 21.
DOI: 10.1111/epi.17010
Abstrakt: Objective: Impaired memory is a common comorbidity of refractory temporal lobe epilepsy (TLE) and often perceived by patients as more problematic than the seizures themselves. The objective of this study is to understand what the relationship of these behavioral impairments is to the underlying pathophysiology, as there are currently no treatments for these deficits, and it remains unknown what circuits are affected.
Methods: We recorded single neurons in the medial temporal lobes (MTLs) of 62 patients (37 with refractory TLE) who performed a visual recognition memory task to characterize the relationship between behavior, tuning, and anatomical location of memory selective and visually selective neurons.
Results: Subjects with a seizure onset zone (SOZ) in the right but not left MTL demonstrated impaired ability to recollect as indicated by the degree of asymmetry of the receiver operating characteristic curve. Of the 1973 recorded neurons, 159 were memory selective (MS) and 366 were visually selective (VS) category cells. The responses of MS neurons located within right but not left MTL SOZs were impaired during high-confidence retrieval trials, mirroring the behavioral deficit seen both in our task and in standardized neuropsychological tests. In contrast, responses of VS neurons were unimpaired in both left and right MTL SOZs. Our findings show that neuronal dysfunction within SOZs in the MTL was specific to a functional cell type and behavior, whereas other cell types respond normally even within the SOZ. We show behavioral metrics that detect right MTL SOZ-related deficits and identify a neuronal correlate of this impairment.
Significance: Together, these findings show that single-cell responses can be used to assess the causal effects of local circuit disruption by an SOZ in the MTL, and establish a neural correlate of cognitive impairment due to epilepsy that can be used as a biomarker to assess the efficacy of novel treatments.
(© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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