Suppressing toxic aggregates: let MIA do it!

Autor: Nowicka U; IMol Polish Academy of Sciences, Warsaw, Poland., Kim MJ; IMol Polish Academy of Sciences, Warsaw, Poland.; Centre of New Technologies, University of Warsaw, Warsaw, Poland., Chacinska A; IMol Polish Academy of Sciences, Warsaw, Poland.; Centre of New Technologies, University of Warsaw, Warsaw, Poland.; ReMedy International Research Agenda Unit, University of Warsaw, Warsaw, Poland.
Jazyk: angličtina
Zdroj: The EMBO journal [EMBO J] 2021 Aug 16; Vol. 40 (16), pp. e109001. Date of Electronic Publication: 2021 Jul 20.
DOI: 10.15252/embj.2021109001
Abstrakt: Mitochondrial activity is becoming an inherent aspect of cellular protein homeostasis (proteostasis). In this issue, Schlagowski et al (2021) report on the attractive notion that modulating mitochondrial protein import activity stimulates protein aggregate clearance in the cytosol, thereby affecting cytosolic proteostasis and its collapse observed in neurodegenerative diseases.
(© 2021 The Authors.)
Databáze: MEDLINE
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