Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation.

Autor: Cellat M; Faculty of Veterinary Medicine, Department of Physiology, Hatay Mustafa Kemal University, 31060, Hatay, Turkey. mcellat@mku.edu.tr., Kuzu M; Faculty of Health Sciences, Department of Nutrition and Dietetics, Karabük University, Karabük, Turkey., İşler CT; Faculty of Veterinary Medicine, Department of Surgery, Hatay Mustafa Kemal University, Hatay, Turkey., Etyemez M; Faculty of Veterinary Medicine, Department of Physiology, Hatay Mustafa Kemal University, 31060, Hatay, Turkey., Dikmen N; Faculty of Medicine, Department of Chest Diseases, Hatay Mustafa Kemal University, Hatay, Turkey., Uyar A; Faculty of Veterinary Medicine, Department of Pathology, Hatay Mustafa Kemal University, Hatay, Turkey., Gökçek İ; Faculty of Veterinary Medicine, Department of Physiology, Hatay Mustafa Kemal University, 31060, Hatay, Turkey., Türk E; Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Hatay Mustafa Kemal University, Hatay, Turkey., Güvenç M; Faculty of Veterinary Medicine, Department of Physiology, Hatay Mustafa Kemal University, 31060, Hatay, Turkey.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2021 Oct; Vol. 394 (10), pp. 2061-2075. Date of Electronic Publication: 2021 Jul 21.
DOI: 10.1007/s00210-021-02117-y
Abstrakt: Asthma is an inflammatory disease that affects many people around the world, especially persons at paediatric age group. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA). For this purpose, four groups, each consisting of eight rats, were arranged. For 21 days, physiological saline solution was treated to the control group and OVA was treated to the groups of OVA, OVA + dexamethasone (Dexa) and OVA + tyrosol groups, intraperitoneally and through inhalation. Additionally, 0.25 mg/kg Dexa was treated to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + tyrosol group by oral gavage. Serum, blood, bronchoalveolar lavage fluid (BALF) and lung tissues of the rats were examined. It was observed that MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in lung tissues of the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-γ and IgE levels decreased compared to the OVA group in lung tissue and serum samples except for serum NF-κB and IL-4. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level on both tissue samples. The results of the histopathological investigation of lung tissue showed that tyrosol significantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was significantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased significantly in blood and BALF samples. The obtained results showed that tyrosol possessed antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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