Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities.

Autor: Hasanin M; Cellulose & Paper Department, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki, Giza, 12622, Egypt., Al Abboud MA; Biology Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia., Alawlaqi MM; Biology Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia., Abdelghany TM; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, 11884, Egypt., Hashem AH; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, 11884, Egypt. amr.hosny86@azhar.edu.eg.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2022 May; Vol. 200 (5), pp. 2099-2112. Date of Electronic Publication: 2021 Jul 20.
DOI: 10.1007/s12011-021-02812-0
Abstrakt: In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), mapping, transmission electron microscope (TEM), and dynamic light scattering (DLS). Results revealed that this nanocomposite is characterized by nano spherical shape ranged around 200 nm as well as doped with CuNPs with size about 9 nm. Antimicrobial, antioxidant, and anticancer activities of the prepared nanocomposite were evaluated. Results revealed that CuNPs-based nanocomposite exhibited outstanding antibacterial and antifungal activity toward Escherichia coli ATCC25922, Bacillus subtilis ATCC605, Candida albicans ATCC90028, Cryptococcus neoformance ATCC 14,116, Aspergillus niger RCMB 02,724, A. terreus RCMB 02,574, and A. fumigatus RCMB 02,568. Moreover, CuNPs-based nanocomposite has a strong antioxidant activity as compared to ascorbic acid, where IC 50 was 18 µg/mL. Cytotoxicity test of CuNPs-based nanocomposite revealed that this nanocomposite is safe in use, where IC 50 was 185.1 µg/mL. Furthermore, CuNPs-based nanocomposite exhibited potential anticancer activity against MCF7 cancerous cell line where IC 50 was 62.8 µg/mL which was better than CuNPs alone. In conclusion, the prepared CuNPs with starch-based nanocomposite is promising for different biomedical applications as antimicrobial, antioxidant, and anticancer activities.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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