Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes.

Autor: Comacchio GM; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Dell'Amore A; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Marino MC; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Russo MD; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Schiavon M; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Mammana M; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Faccioli E; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy., Lorenzoni G; Unit of Biostatistics, Epidemiology and Public Health, University of Padua, 35131 Padua, Italy., Gregori D; Unit of Biostatistics, Epidemiology and Public Health, University of Padua, 35131 Padua, Italy., Pasello G; Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, 35128 Padua, Italy., Marulli G; Thoracic Surgery Unit, University Hospital of Bari, 70124 Bari, Italy., Rea F; Thoracic Surgery and Lung Transplant Unit, University Hospital of Padua, 35128 Padua, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2021 Jul 04; Vol. 13 (13). Date of Electronic Publication: 2021 Jul 04.
DOI: 10.3390/cancers13133355
Abstrakt: Background: The involvement of mediastinal great vessels is common in advanced stage thymic tumors, which makes their surgical resection challenging. Moreover, the impact of vascular involvement on the oncological prognosis is still unclear. The aim of this study is to investigate the surgical and oncological outcomes and the impact of vascular involvement in a population of patients operated for advanced stage thymic tumors.
Methods: A retrospective analysis on four hundred and sixty-five patients undergoing resection for advanced stage (Masaoka III-IV) thymic tumors in a single high-volume center was performed. One hundred forty-four patients met the inclusion criteria and were eligible for the study. Patients were divided in two groups according to the presence or absence of vascular involvement.
Results: the two groups did not differ for the baseline characteristics and showed comparable surgical outcomes. Vascular involvement was not associated with worse overall survival but with an increased recurrence rate ( p = 0.03). Multivariable analysis demonstrated a higher risk of recurrence in patients without R0 resection (HR 0.11, 0.02-0.54, p = 0.006) and with thymic carcinoma (HR 2.27, 1.22-4.24, p = 0.01).
Conclusions: resection of thymic tumors with vascular involvement can be performed with optimal surgical results in a high volume center. From the oncological point of view, the involvement of the great vessels seems to be associated with a higher recurrence rate without affecting long-term survival.
Databáze: MEDLINE
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