Low pan-immune-inflammation-value predicts better chemotherapy response and survival in breast cancer patients treated with neoadjuvant chemotherapy.

Autor: Şahin AB; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey. absahin@uludag.edu.tr., Cubukcu E; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey., Ocak B; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey., Deligonul A; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey., Oyucu Orhan S; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey., Tolunay S; Department of Pathology, School of Medicine, Bursa Uludag University, Bursa, Turkey., Gokgoz MS; School of Medicine, General Surgery, Bursa Uludag University, Bursa, Turkey., Cetintas S; Department of Radiation Oncology, School of Medicine, Bursa Uludag University, Bursa, Turkey., Yarbas G; Department of Internal Medicine, School of Medicine, Bursa Uludag University, Bursa, Turkey., Senol K; School of Medicine, General Surgery, Bursa Uludag University, Bursa, Turkey., Goktug MR; Department of Internal Medicine, School of Medicine, Bursa Uludag University, Bursa, Turkey., Yanasma ZB; Department of Internal Medicine, School of Medicine, Bursa Uludag University, Bursa, Turkey., Hasanzade U; Department of Internal Medicine, School of Medicine, Bursa Uludag University, Bursa, Turkey., Evrensel T; Department of Medical Oncology, School of Medicine, Bursa Uludag University, 16059, Gorukle, Nilufer, Bursa, Turkey.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jul 19; Vol. 11 (1), pp. 14662. Date of Electronic Publication: 2021 Jul 19.
DOI: 10.1038/s41598-021-94184-7
Abstrakt: Blood-based biomarkers reflect systemic inflammation status and have prognostic and predictive value in solid malignancies. As a recently defined biomarker, Pan-Immune-Inflammation-Value (PIV) integrates different peripheral blood cell subpopulations. This retrospective study of collected data aimed to assess whether PIV may predict the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in Turkish women with breast cancer. The study consisted of 743 patients with breast cancer who were scheduled to undergo NAC before attempting cytoreductive surgery. A pre-treatment complete blood count was obtained in the two weeks preceding NAC, and blood-based biomarkers were calculated from absolute counts of relevant cell populations. The pCR was defined as the absence of tumor cells in both the mastectomy specimen and lymph nodes. Secondary outcome measures included disease-free survival (DFS) and overall survival (OS). One hundred seven patients (14.4%) had pCR. In receiver operating characteristic analysis, optimal cut-off values for the neutrophile-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte (PLR), PIV, and Ki-67 index were determined as ≥ 2.34, ≥ 0.22, ≥ 131.8, ≥ 306.4, and  ≥ 27, respectively. The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses. However, multivariate analysis revealed that the clinical T stage, PIV, ER status, HER-2 status, and Ki-67 index were independent predictors for pCR. Moreover, the low PIV group patients had significantly better DFS and OS than those in the high PIV group (p = 0.034, p = 0.028, respectively). Based on our results, pre-treatment PIV seems as a predictor for pCR and survival, outperforming NLR, MLR, PLR in predicting pCR in Turkish women with breast cancer who received NAC. However, further studies are needed to confirm our findings.
(© 2021. The Author(s).)
Databáze: MEDLINE
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