Frequency and phenotype of headache in covid-19: a study of 2194 patients.

Autor: García-Azorín D; Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal N° 3, 47003, Valladolid, Spain. davilink@hotmail.com., Sierra Á; Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal N° 3, 47003, Valladolid, Spain., Trigo J; Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal N° 3, 47003, Valladolid, Spain., Alberdi A; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Blanco M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Calcerrada I; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Cornejo A; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Cubero M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Gil A; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., García-Iglesias C; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Lozano AG; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Martínez Badillo C; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Montilla C; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Mora M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Núñez G; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Paniagua M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Pérez C; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Rojas M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Ruiz M; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Sierra L; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Hurtado ML; Valladolid East Primary Care Basic Health Area, Valladolid, Spain., Guerrero Peral ÁL; Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal N° 3, 47003, Valladolid, Spain.; Department of Medicine and toxicology, University of Valladolid, Valladolid, Spain.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jul 19; Vol. 11 (1), pp. 14674. Date of Electronic Publication: 2021 Jul 19.
DOI: 10.1038/s41598-021-94220-6
Abstrakt: To estimate the frequency of headache in patients with confirmed COVID-19 and characterize the phenotype of headache attributed to COVID-19, comparing patients depending on the need of hospitalization and sex, an observational study was done. We systematically screened all eligible patients from a reference population of 261,431 between March 8 (first case) and April 11, 2020. A physician administered a survey assessing demographic and clinical data and the phenotype of the headache. During the study period, 2194 patients out of the population at risk were diagnosed with COVID-19. Headache was described by 514/2194 patients (23.4%, 95% CI 21.7-25.3%), including 383/1614 (23.7%) outpatients and 131/580 (22.6%) inpatients. The headache phenotype was studied in detail in 458 patients (mean age, 51 years; 72% female; prior history of headache, 49%). Headache was the most frequent first symptom of COVID-19. Median headache onset was within 24 h, median duration was 7 days and persisted after 1 month in 13% of patients. Pain was bilateral (80%), predominantly frontal (71%), with pressing quality (75%), of severe intensity. Systemic symptoms were present in 98% of patients. Headache frequency and phenotype was similar in patients with and without need for hospitalization and when comparing male and female patients, being more intense in females.Trial registration: This study was supported by the Institute of Health Carlos III (ISCIII), code 07.04.467804.74011 and Regional Health Administration, Gerencia Regional de Salud, Castilla y Leon (GRS: 2289/A/2020).
(© 2021. The Author(s).)
Databáze: MEDLINE
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