TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice.

Autor: Peres DS; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Theisen MC; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Fialho MFP; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Dalenogare DP; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Rodrigues P; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Kudsi SQ; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Bernardes LB; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Ruviaro da Silva NA; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Lückemeyer DD; Federal University of Santa Catarina (UFSC), Florianopolis, SC, 88040-900, Brazil., Sampaio TB; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Pereira GC; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Mello FK; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Ferreira J; Federal University of Santa Catarina (UFSC), Florianopolis, SC, 88040-900, Brazil., Bochi GV; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Oliveira SM; Toxicological Biochemistry, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., de David Antoniazzi CT; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil. Electronic address: carenantoniazzi@yahoo.com.br., Trevisan G; Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil. Electronic address: gabrielatrevisansantos@gmail.com.
Jazyk: angličtina
Zdroj: Brain research bulletin [Brain Res Bull] 2021 Oct; Vol. 175, pp. 1-15. Date of Electronic Publication: 2021 Jul 16.
DOI: 10.1016/j.brainresbull.2021.07.011
Abstrakt: Progressive multiple sclerosis (PMS) is a neurological disease associated with the development of depression and anxiety, but treatments available are unsatisfactory. The transient receptor potential ankyrin 1 (TRPA1) is a cationic channel activated by reactive compounds, and the blockage of this receptor can reduce depression- and anxiety-like behaviors in naive mice. Thus, we investigated the role of TRPA1 in depression- and anxiety-like behaviors in a PMS model in mice. PMS model was induced in C57BL/6 female mice by the experimental autoimmune encephalomyelitis (EAE). Nine days after the PMS-EAE induction, behavioral tests (tail suspension and elevated plus maze tests) were performed to verify the effects of sertraline (positive control), selective TRPA1 antagonist (A-967,079), and antioxidants (α-lipoic acid and apocynin). The prefrontal cortex and hippocampus were collected to evaluate biochemical and inflammatory markers. PMS-EAE induction did not cause locomotor changes but triggered depression- and anxiety-like behaviors, which were reversed by sertraline, A-967,079, α-lipoic acid, or apocynin treatments. The neuroinflammatory markers (AIF1, GFAP, IL-1β, IL-17, and TNF-α) were increased in mice's hippocampus. Moreover, this model did not alter TRPA1 RNA expression levels in the hippocampus but decrease TRPA1 levels in the prefrontal cortex. Moreover, PMS-EAE induced an increase in NADPH oxidase and superoxide dismutase activities and TRPA1 endogenous agonist levels (hydrogen peroxide and 4-hydroxynonenal). TRPA1 plays a fundamental role in depression- and anxiety-like behaviors in a PMS-EAE model; thus, it could be a possible pharmacological target for treating these symptoms in PMS.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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