SARS-CoV-2 Variants in Rhode Island.
| Autor: | Kantor R; Division of Infectious Diseases, Alpert Medical School of Brown University, Providence, RI., Novitsky V; Division of Infectious Diseases, Alpert Medical School of Brown University, Providence, RI., Carpenter-Azevedo K; Rhode Island Department of Health, State Health Laboratories, Providence, RI., Howison M; Research Improving People's Life, Providence, RI., Manne A; Division of Infectious Diseases, Alpert Medical School of Brown University, Providence, RI., Darpolor JK; Division of Infectious Diseases, Alpert Medical School of Brown University, Providence, RI., Bobenchik A; Rhode Island Hospital, Providence, RI., Tripathi A; Brown University School of Engineering, Providence, RI., Huard RC; Rhode Island Department of Health, State Health Laboratories, Providence, RI., King E; Rhode Island Department of Health, State Health Laboratories, Providence, RI. |
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| Jazyk: | angličtina |
| Zdroj: | Rhode Island medical journal (2013) [R I Med J (2013)] 2021 Sep 01; Vol. 104 (7), pp. 16-20. Date of Electronic Publication: 2021 Sep 01. |
| Abstrakt: | COVID-19 is a worldwide public health emergency caused by SARS-CoV-2. Genomic surveillance of SARS-CoV-2 emerging variants is important for pandemic monitoring and informing public health responses. Through an interstate academic-public health partnership, we established Rhode Island's capacity to sequence SARS-CoV-2 genomes and created a systematic surveillance program to monitor the prevalence of SARS-CoV-2 variants in the state. We describe circulating SARS-CoV-2 lineages in Rhode Island; provide a timeline for the emerging and expanding contribution of variants of concern (VOC) and variants of interest (VOI), from their first introduction to their eventual predominance over other lineages; and outline the frequent identification of known adaptively beneficial spike protein mutations that appear to have independently arisen in non-VOC/non-VOI lineages. Overall, the described Rhode Island- centric genomic surveillance initiative provides a valuable perspective on SARS-CoV-2 in the state and contributes data of interest for future epidemiological studies and state-to-state comparisons. |
| Databáze: | MEDLINE |
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