Longitudinal Changes in Hippocampal Network Connectivity in Alzheimer's Disease.

Autor: Dautricourt S; Normandie Univ, UNICAEN, INSERM, PhIND.; Neurology Department, Caen-Normandie University Hospital, Caen, France., de Flores R; Normandie Univ, UNICAEN, INSERM, PhIND., Landeau B; Normandie Univ, UNICAEN, INSERM, PhIND., Poisnel G; Normandie Univ, UNICAEN, INSERM, PhIND., Vanhoutte M; Normandie Univ, UNICAEN, INSERM, PhIND., Delcroix N; CNRS, Unité Mixte de Service-3408, GIP CYCERON, Bd Henri Becquerel, BP5229, 14074 Caen cedex, France., Eustache F; Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France., Vivien D; Normandie Univ, UNICAEN, INSERM, PhIND.; Department of Clinical Research, Caen-Normandie University Hospital, Caen, France., de la Sayette V; Neurology Department, Caen-Normandie University Hospital, Caen, France.; Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France., Chételat G; Normandie Univ, UNICAEN, INSERM, PhIND.
Jazyk: angličtina
Zdroj: Annals of neurology [Ann Neurol] 2021 Sep; Vol. 90 (3), pp. 391-406. Date of Electronic Publication: 2021 Aug 06.
DOI: 10.1002/ana.26168
Abstrakt: Objective: The hippocampus is connected to 2 distinct cortical brain networks, the posterior-medial and the anterior-temporal networks, involving different medial temporal lobe (MTL) subregions. The aim of this study was to assess the functional alterations of these 2 networks, their changes over time, and links to cognition in Alzheimer's disease.
Methods: We assessed MTL connectivity in 53 amyloid-β-positive patients with mild cognitive impairment and AD dementia and 68 healthy elderly controls, using resting-state functional magnetic resonance imaging, cross-sectionally and longitudinally. First, we compared the functional connectivity of the posterior-medial and anterior-temporal networks within the control group to highlight their specificities. Second, we compared the connectivity of these networks between groups, and between baseline and 18-month follow-up in patients. Third, we assessed the association in the connectivity changes between the 2 networks, and with cognitive performance.
Results: We found decreased connectivity in patients specifically between the hippocampus and the posterior-medial network, together with increased connectivity between several MTL subregions and the anterior-temporal network. Moreover, changes in the posterior-medial and anterior-temporal networks were interrelated such that decreased MTL-posterior-medial connectivity was associated with increased MTL-anterior-temporal connectivity. Finally, both MTL-posterior-medial decrease and MTL-anterior-temporal increase predicted cognitive decline.
Interpretation: Our findings demonstrate that longitudinal connectivity changes in the posterior-medial and anterior-temporal hippocampal networks are linked together and that they both contribute to cognitive decline in Alzheimer's disease. These results shed light on the critical role of the posterior-medial and anterior-temporal networks in Alzheimer's disease pathophysiology and clinical symptoms. ANN NEUROL 2021;90:391-406.
(© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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