Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review.

Autor: Lin J; Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Emory University Atlanta GA USA., Sorrells MG; Department of Chemical and Biological Engineering Colorado School of Mines Golden CO USA., Lam WA; Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Emory University Atlanta GA USA.; Division of Pediatric Hematology/Oncology Department of Pediatrics Aflac Cancer Center and Blood Disorder Service of Children's Healthcare of Atlanta Emory University School of Medicine Atlanta GA USA., Neeves KB; Department of Bioengineering University of Colorado Denver Anschutz Medical Campus Aurora CO USA.; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant, Hemophilia and Thrombosis Center University of Colorado Denver Anschutz Medical Campus Aurora CO USA.
Jazyk: angličtina
Zdroj: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2021 Jul 14; Vol. 5 (5), pp. e12548. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
DOI: 10.1002/rth2.12548
Abstrakt: This illustrated review focuses on the physical forces that regulate hemostasis and thrombosis. These phenomena span from the vessel to the cellular to the molecular scales. Blood is a complex fluid with a viscosity that varies with how fast it flows and the size of the vessel through which it flows. Blood flow imposes forces on the vessel wall and blood cells that dictates the kinetics, structure, and stability of thrombi. The mechanical properties of blood cells create a segmented flowing fluid whereby red blood cells concentrate in the vessel core and platelets marginate to the near-wall region. At the vessel wall, shear stresses are highest, which requires a repertoire of receptors with different bond kinetics to roll, tether, adhere, and activate on inflamed endothelium and extracellular matrices. As a thrombus grows and then contracts, forces regulate platelet aggregation as well as von Willebrand factor function and fibrin mechanics. Forces can also originate from platelets as they respond to the external forces and sense the stiffness of their local environment.
(© 2021 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).)
Databáze: MEDLINE
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