Nationwide population-based surveys of Iranian COVID-19 Serological Surveillance (ICS) program: The surveys protocol.

Autor:	Khalagi K; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Gharibzadeh S; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran., Khalili D; Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mirab Samiee S; Reference Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran., Hashemi SM; Departments of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Aghamohamadi S; Deputy of Health, Ministry of Health and Medical Education, Tehran, Iran., Mir-Mohammad-Ali Roodaki M; Reference Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran., Tayeri K; National HIV/AIDS care and treatment advisor, Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran., Namdari Tabar H; HIV/STI Control Department, Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran., Azadmanesh K; Virology Deportment, Pasteur Institute of Iran, Tehran, Iran., Tabrizi JS; Tabriz Health Services Management Research Center, Iranian Center of Excellence in Health Management, Tabriz University of Medical Sciences, Tabriz, Iran., Mohammad K; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Goudarzi S; Department of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran, Iran., Hajipour F; Endocrinology Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Namaki S; Departments of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Raeisi A; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Ostovar A; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Medical journal of the Islamic Republic of Iran [Med J Islam Repub Iran] 2021 May 12; Vol. 35, pp. 61. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
DOI:	10.47176/mjiri.35.61
Abstrakt:	Background: Serological surveillance of COVID-19 through conducting repetitive population-based surveys can be useful in estimating and monitoring changes in the prevalence of infection across the country. This paper presents the protocol of nationwide population-based surveys of the Iranian COVID-19 Serological Surveillance (ICS) program. Methods: The target population of the surveys is all individuals ≥6 years in Iran. Stratified random sampling will be used to select participants from those registered in the primary health care electronic record systems in Iran. The strata are the 31 provinces of the country, in which sampling will be done through simple random sampling. The sample size is estimated 858 individuals for each province (except for Tehran province, which is 2574) at the first survey. It will be recalculated for the next surveys based on the findings of the first survey. The participants will be invited by the community health workers to the safe blood sampling centers at the district level. After obtaining written informed consent, 10 mL of venous blood will be taken from the participants. The blood samples will be transferred to selected reference laboratories in order to test IgG and IgM antibodies against COVID-19 using an Iranian SARS-CoV-2 ELISA Kit (Pishtaz Teb). A serologically positive test is defined as a positive IgG, IgM, or both. After adjusting for the measurement error of the laboratory test, nonresponse bias, and sampling design, the prevalence of COVID-19 will be estimated at the provincial and national levels. Also, the approximate incidence rate of infection will be calculated based on the data of both consecutive surveys. Conclusion: The implementation of these surveys will provide a comprehensive and clear picture of the magnitude of COVID-19 infection and its trend over time for health policymakers at the national and subnational levels. Competing Interests: Conflicts of Interest: SN and AR are the Minister of Health and Medical Education and Deputy Minister of Public Health of MOHME in Iran, respectively. SMS, SMH, SA, MMR, KT, HNT, JST, and AO have also a position in MOHME. The rest of the authors declare no conflict of interest, real or perceived. (© 2021 Iran University of Medical Sciences.)
Databáze:	MEDLINE
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