Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe.

Autor:	Elsouri K; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Arboleda V; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Heiser S; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, USA., Kesselman MM; Rheumatology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA., Demory Beckler M; Microbiology and Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Jun 09; Vol. 13 (6), pp. e15543. Date of Electronic Publication: 2021 Jun 09 (Print Publication: 2021).
DOI:	10.7759/cureus.15543
Abstrakt:	Rheumatoid arthritis (RA) and celiac disease (CD) are both autoimmune diseases with increasing global prevalence. These two diseases have been connected based on similar HLA mutations, serological markers, rheumatological, and gastrointestinal manifestations. In this review, we discuss the role of the oral and gut microbiome in the development and progression of RA and CD. Here, we highlight similar microbial dysbiosis and how these alterations in composition can lead to worsening disease severity in both CD and RA. Additionally, we analyze the role of probiotics in regulating the microbiome and improving symptoms associated with RA and CD. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Elsouri et al.)
Databáze:	MEDLINE
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