Intensity modulated radiotherapy in carcinoma cervix with metastatic para-aortic nodes: an institutional experience from a Regional Cancer Centre of Eastern India.

Autor:	Biplab M; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India., Tapas M; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India., Debarshi L; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India., Sanjoy R; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India., Prabir C; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India., Dilip RK; Department of Radiotherapy, Chittaranjan National Cancer Institute, Kolkata, India.
Jazyk:	angličtina
Zdroj:	Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2021 Jun 09; Vol. 26 (3), pp. 400-407. Date of Electronic Publication: 2021 Jun 09 (Print Publication: 2021).
DOI:	10.5603/RPOR.a2021.0063
Abstrakt:	Background: Cervical cancer is a major health problem, especially in developing countries like India. Extended field radiotherapy (EFRT) for cancer cervix treatment remains a challenging task for radiation oncologists. In the last decade studies have shown that EFRT using intensity modulated radiotherapy (IMRT) is feasible in treating gynaecological malignancies but there is a dearth of literature on this specific topic from this part of the world where patient profile differs greatly in several aspects from that of the western world. The aim of the study was evaluation of treatment response and toxicity profile in cases of carcinoma cervix with metastatic para-aortic nodes treated with intensity modulated radiotherapy technique. Materials and Methods: In this retrospective study the treatment records of 45 para-aortic node positive cervical cancer patients treated with EFRT (IMRT) and concurrent cisplatin were analysed for evaluation of loco-regional control and toxicities. Results: Forty-four patients received full course of treatment. Among those 44 patients, 93.2% achieved complete response. Overall, the treatment was tolerated well and toxicities were within acceptable limits. Acute grade 3-4 toxicities were observed mostly in the form of anaemia and leucopenia. Most common late toxicities were those of small and large intestine. Conclusion: EFRT with concurrent chemotherapy was successfully delivered for para-aortic nodes positive cervical cancer patients in Indian scenario where under-nutrition, infection, anaemia and several other factors adversely influence treatment outcome. Pelvic and para-aortic control rates were satisfactory. The technique was associated with an acceptable acute and late toxicity profile. Competing Interests: Conflict of interest None declared. (© 2021 Greater Poland Cancer Centre.)
Databáze:	MEDLINE
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