Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival.

Autor:	Soliman DSA; Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.; Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Clinical Pathology, National Cancer Institute, Cairo, Egypt., El Sabah H; Department of Clinical Pathology, National Cancer Institute, Cairo, Egypt., Ganwo I; Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar., Amer A; Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar., Taha RY; Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar., Szabados L; PET/CT Center, Clinical Imaging, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar., Eldean MS; Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar., Al-Sabbagh A; Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar., Ibrahim F; Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2021 Jul 01; Vol. 13 (1), pp. e2021043. Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021).
DOI:	10.4084/MJHID.2021.043
Abstrakt:	Background: Plasma cell neoplasms can show aberrant expression of different lineage-related antigens; however, co-expression of T-cell-associated markers on malignant plasma cells is extremely rare. Material and Methods: This report describes clinicopathologic characteristics of three myeloma patients with emergent plasmablastic morphology and aberrant acquisition of T-cell-associated markers diagnosed in our center. An extensive literature search for similar cases was conducted, and the relevant pathologic, clinical, and prognostic characteristics were summarized. Results: A total of 22 cases of plasma cell neoplasm (including the three cases reported here) showed aberrant co-expression of T-cell markers. We found an evident association between aberrant expression of T-cell markers on malignant plasma cells and extramedullary involvement, aggressive morphologic features, high proliferative index ki67 >90%, aggressive clinical course, an adverse outcome, and short survival. Discussion & Conclusion: Due to the rarity of this aberrant phenotype and scarcity of the published data, the precise causative mechanism and its clinical implications have not yet been elucidated. Competing Interests: Competing interests: The authors declare no conflict of Interest.
Databáze:	MEDLINE
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