Usefulness of neutrophil-to-lymphocyte ratio for predicting acute pericarditis outcomes.
| Autor: | Yılmaz F; Kartal Kosuyolu Research and Education Hospital, Kartal, Turkey., Yılmaz FK; Faculty of Medicine, Cardiology Department, Medipol University, Istanbul, Turkey., Karagöz A; Kartal Kosuyolu Research and Education Hospital, Kartal, Turkey., Yıldırım A; Faculty of Medicine, Cardiology Department, Medipol University, Istanbul, Turkey., Gunes HM; Faculty of Medicine, Cardiology Department, Medipol University, Istanbul, Turkey., Akbas RB; Kartal Kosuyolu Research and Education Hospital, Kartal, Turkey., Efe SÇ; Kartal Kosuyolu Research and Education Hospital, Kartal, Turkey., Barutçu İ; Faculty of Medicine, Cardiology Department, Medipol University, Istanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Acta cardiologica [Acta Cardiol] 2022 Jul; Vol. 77 (5), pp. 422-430. Date of Electronic Publication: 2021 Jul 19. |
| DOI: | 10.1080/00015385.2021.1951998 |
| Abstrakt: | Background: In daily practice, C-reactive protein (CRP) may be used to predict recurrence and treatment response in patients with acute pericarditis; however, the predictive role of CRP might be insufficient for clinical prediction in some patients. In this study, we aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and the composite endpoint of pericarditis recurrence and/or tamponade within 1 year in patients with acute pericarditis. Methods: A total of 104 patients diagnosed with acute idiopathic pericarditis (mean age 42.8 ± 15.2 years, 55.8% male) were included in the study. Physical examination findings of these patients, electrocardiography, echocardiography, chest X-ray and laboratory findings were evaluated and analysed. During the 1-year follow-up, the composite of cardiac tamponade and/or pericarditis recurrence was investigated as the primary endpoint of the study. Results: Compared to the group without the composite outcome, the group with the composite outcome had significantly higher rates of moderate and severe pericardial effusion ( p < 0.01) and higher white blood cell (WBC) count (p:0.001), platelet count ( p = 0.003), NLR (2.14 (1.49-3.02) vs 6.60 (5.50-8.68); p < 0.001) and high-sensitivity C-reactive protein (hs-CRP) (8.01 (5.1-24.5 vs 69.5 (40.8-128); p:0.001). Higher hs-CRP ( p < 0.001), WBC (p:0.001), NLR ( p < 0.001) and platelets (p:0.02) were associated with pericarditis recurrence. NLR and hs-CRP were independently associated with the composite endpoint ( p < 0.001 and p < 0.001, respectively). Conclusion: NLR and hs-CRP were found to be independent predictors for the composite endpoint of tamponade and/or recurrence in acute pericarditis patients during the 1-year follow-up. Similar to hs-CRP, NLR may also be used for risk assessment in patients with idiopathic pericarditis. |
| Databáze: | MEDLINE |
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