Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

Autor: Rao VN; Division of Cardiology, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina. Electronic address: vishal.rao@duke.edu., Obeid MJ; Division of Cardiology, Duke University Medical Center, Durham, North Carolina., Rigiroli F; Department of Radiology, Duke University Medical Center, Durham, North Carolina., Russell SD; Division of Cardiology, Duke University Medical Center, Durham, North Carolina., Patel CB; Division of Cardiology, Duke University Medical Center, Durham, North Carolina., Molinger J; Division of Cardiology, Duke University Medical Center, Durham, North Carolina., Gupta RT; Department of Radiology, Duke University Medical Center, Durham, North Carolina; Department of Surgery, Duke University Medical Center, Durham, North Carolina; Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, North Carolina., Agarwal R; Division of Cardiology, Duke University Medical Center, Durham, North Carolina., Fudim M; Division of Cardiology, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
Jazyk: angličtina
Zdroj: Journal of cardiac failure [J Card Fail] 2022 Jan; Vol. 28 (1), pp. 149-153. Date of Electronic Publication: 2021 Jul 16.
DOI: 10.1016/j.cardfail.2021.06.021
Abstrakt: Background: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF undergoing left ventricular assist device (LVAD) implantation. This study aimed to evaluate the associations between PAT and LVAD-associated outcomes.
Methods and Results: We retrospectively measured computed tomography-derived PAT volumes in 77 consecutive adults who had available chest CT imaging prior to HeartMate 3 LVAD surgery between October 2015 and March 2019 at Duke University Hospital. Study groups were divided into above-median (≥219 cm 3 ) and below-median (<219 cm 3 ) PAT volume. Those with above-median PAT had a higher proportion of atrial fibrillation, chronic kidney disease and ischemic cardiomyopathy. Groups with above-median vs below-median PAT had similar Kaplan-Meier incidence rates over 2 years for (1) composite all-cause mortality, redo-LVAD surgery and cardiac transplantation (35.9 vs 32.2%; log-rank P = 0.65) and (2) composite incident hospitalizations for HF, gastrointestinal bleeding, LVAD-related infection, and stroke (61.5 vs 60. 5 %; log-rank P = 0.67).
Conclusions: In patients with end-stage HF undergoing LVAD therapy, PAT is not associated with worse 2-year LVAD-related outcomes. The significance of regional adiposity vs obesity in LVAD patients warrants further investigation.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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