Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh.

Autor: Farzan SF; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States. Electronic address: sffarzan@usc.edu., Shahriar M; UChicago Research Bangladesh, Dhaka, Bangladesh; Department of Public Health Sciences, University of Chicago, Chicago, IL, 60637, United States., Kibriya MG; Department of Public Health Sciences, University of Chicago, Chicago, IL, 60637, United States., Jasmine F; Department of Public Health Sciences, University of Chicago, Chicago, IL, 60637, United States., Sarwar G; UChicago Research Bangladesh, Dhaka, Bangladesh., Slavkovic V; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, United States., Graziano JH; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, United States., Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, IL, 60637, United States., Argos M; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL 60612, United States.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2021 Nov; Vol. 156, pp. 106765. Date of Electronic Publication: 2021 Jul 15.
DOI: 10.1016/j.envint.2021.106765
Abstrakt: Background: Telomere length has been associated with the occurrence and progression of common chronic and age-related diseases, and in younger populations, may represent a biomarker of disease susceptibility. Early childhood is a critical period for telomere biology as this period is characterized by a rapid decline in telomere length due to a large turnover of highly proliferative cells and may represent a period of unique sensitivity to environmental insults. Arsenic (As) exposure has been associated with both telomere lengthening and shortening in adults and children and some evidence suggests the effects may differ by level and timing of exposure.
Objectives: Given the lack of clarity across studies, we investigated the association between urinary As and leukocyte telomere length among 476 five- to seven-year-old children enrolled in the Bangladesh Environmental Research in Children's Health (BiRCH) cohort.
Methods: In a series of multivariable models, adjusted for key covariates, we examined associations between urinary As and relative telomere length (RTL) of whole blood DNA.
Results: We observed small but consistent, negative associations between urinary As and RTL, such that a doubling of urinary As was associated with a -0.017 (95% CI: -0.030, -0.005; p = 0.0056) decrease in RTL, in fully adjusted models. We also observed a somewhat stronger inverse relationship between urinary As concentration and RTL among children born to fathers ≥ 30 years of age at the time of birth, than those < 30 years; however, we did not observe a statistically significant interaction.
Discussion: Our study suggests that As influences RTL, with detectable associations in early to mid-childhood. Further studies are needed to confirm our findings and investigate the potential long-term impacts of telomere shortening in childhood on later life health outcomes. Additional studies exploring how dose and timing of exposure may relate to RTL are critical to understanding As's relationship to telomere length.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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