Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.

Autor: Magalhães LS; Laboratory of Molecular Biology and Immunology, Federal University of Sergipe, Aracaju, Brazil., Bomfim LGS; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil., Santos CNO; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil., Dos Santos PL; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.; Department of Health Education, Federal University of Sergipe, Lagarto, Brazil., Tanajura DM; Department of Health Education, Federal University of Sergipe, Lagarto, Brazil., Lipscomb MW; Department of Biology, Howard University, Washington, D.C., USA., de Jesus AR; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.; Instituto de Investigação Em Imunologia, São Paulo, Brazil., de Almeida RP; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.; Instituto de Investigação Em Imunologia, São Paulo, Brazil., de Moura TR; Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil. tmoura.ufs@gmail.com.; Department of Morphology, Federal University of Sergipe, São Cristóvão, Brazil. tmoura.ufs@gmail.com.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2021 Aug; Vol. 120 (8), pp. 2959-2964. Date of Electronic Publication: 2021 Jul 17.
DOI: 10.1007/s00436-021-07231-7
Abstrakt: Visceral leishmaniasis is a severe disease caused by protozoan parasites that include Leishmania (L.) infantum. The disease is established when parasites subvert the immune response of the host. Notably, chemotherapy-based use of antimonial compounds can partially alleviate disease burden. Unfortunately, the resistance to drug treatments is increasing in areas endemic to the disease. In this report, we investigated immune responses within macrophages infected with antimony-resistant L. infantum isolates from patients with a relapse in the disease. Results revealed that antimony-resistant parasites persist in the first 24 h of infection. Activation of macrophage or blocking of thiol production during infection shows enhanced clearance of parasites, which is coordinately associated with increased production of pro-inflammatory cytokines. Taken together, these results suggest that the mechanism of antimony resistance in L. infantum isolates may be related to a decrease in macrophage microbicidal functions.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: