Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance.
| Autor: | Ring B; Indianapolis, IN, USA., Wrighton SA; East Troy, WI, USA., Mohutsky M; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. mohutskyma@lilly.com. |
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| Jazyk: | angličtina |
| Zdroj: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2342, pp. 29-50. |
| DOI: | 10.1007/978-1-0716-1554-6_2 |
| Abstrakt: | Inhibition of a drug-metabolizing enzyme by the reversible interaction of a drug with the enzyme, thus decreasing the metabolism of another drug, is a major cause of clinically significant drug-drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug-drug interactions resulting from reversible inhibition are described. (© 2021. Springer Science+Business Media, LLC, part of Springer Nature.) |
| Databáze: | MEDLINE |
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