Biomedical application of graphitic carbon nitrides: tissue deposition in vivo , induction of reactive oxygen species (ROS) and cell viability in tumor cells.

Autor: Freire TM; Group of Chemistry of Advanced Materials (GQMat)- Department of Analytical Chemistry and Physical-Chemistry, Federal University of Ceará, Fortaleza-CE, 451-970, Brazil., Sant'Anna C; National Institute of Metrology, Quality and Technology, Laboratory of Microscopy Applied to Life Science, Duque de Caxias-RJ, 24250020, Brazil., Yoshihara N; National Institute of Metrology, Quality and Technology, Laboratory of Microscopy Applied to Life Science, Duque de Caxias-RJ, 24250020, Brazil., Hu R; Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China., Qu J; Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China., Alencar LMR; Federal University of Maranhão, Department of Physics, Biophysics Laboratory, Campus Bacanga, São Luís-MA, 65080-805, Brazil., Oliveira da Silva de Barros A; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro-RJ, 21941906, Brazil., Helal-Neto E; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro-RJ, 21941906, Brazil., Fernandes LR; Laboratory of Biology of Endothelial Cells and Angiogenesis (LabAngio), Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro-RJ 20550- 900, Brazil.; Zona Oeste State University, Laboratory of Nanoradiophasrmacy and Strategic Biomaterials, Rio de Janeiro-RJ, 220000, Brazil., Simoes RL; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro-RJ, 21941906, Brazil.; Zona Oeste State University, Laboratory of Nanoradiophasrmacy and Strategic Biomaterials, Rio de Janeiro-RJ, 220000, Brazil.; Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro-RJ 21040900, Brazil., Barja-Fidalgo C; Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro-RJ 21040900, Brazil., Fechine PBA; Group of Chemistry of Advanced Materials (GQMat)- Department of Analytical Chemistry and Physical-Chemistry, Federal University of Ceará, Fortaleza-CE, 451-970, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro-RJ, 21941906, Brazil.; Zona Oeste State University, Laboratory of Nanoradiophasrmacy and Strategic Biomaterials, Rio de Janeiro-RJ, 220000, Brazil.
Jazyk: angličtina
Zdroj: Nanotechnology [Nanotechnology] 2021 Aug 02; Vol. 32 (43). Date of Electronic Publication: 2021 Aug 02.
DOI: 10.1088/1361-6528/ac1540
Abstrakt: The urgency for new materials in oncology is immediate. In this study we have developed the g-C 3 N 4 , a graphitic-like structure formed by periodically linked tris-s-triazine units. The g-C 3 N 4 has been synthesized by a simple and fast thermal process. XRD has shown the formation of the crystalline sheet with a compacted structure. The graphite-like structure and the functional groups have been shown by Raman and FTIR spectroscopy. TEM image and AFM revealed the porous composed of five or six C-N layers stacked. DRS and Photoluminescence analyses confirmed the structure with band gap of 2.87 eV and emission band at 448 nm in different wavelengths excitation conditions. The biological results showed inhibitory effect on cancer cell lines and non-toxic effect in normal cell lines. To the best of our knowledge, this is the first work demonstrating the cytotoxic effects of 2D g-C 3 N 4 in a cancer cell line, without any external or synergistic influence. The biodistribution/tissue accumulation showed that g-C 3 N 4 present a tendency to accumulation on the lung in the first 2 h, but after 24 h the profile of the biodistribution change and it is found mainly in the liver. Thus, 2D-g-C 3 N 4 showed great potential for the treatment of several cancer types.
(© 2021 IOP Publishing Ltd.)
Databáze: MEDLINE
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