Using Network Parcels and Resting-State Networks to Estimate Correlates of Mood Disorder and Related Research Domain Criteria Constructs of Reward Responsiveness and Inhibitory Control.

Autor: Langenecker SA; Department of Psychiatry, University of Utah, Salt Lake City, Utah. Electronic address: s.langenecker@hsc.utah.edu., Westlund Schreiner M; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Thomas LR; Department of Psychiatry, University of Utah, Salt Lake City, Utah; Department of Psychology, University of Utah, Salt Lake City, Utah., Bessette KL; Department of Psychiatry, University of Utah, Salt Lake City, Utah; Department of Psychiatry & Psychology, University of Illinois at Chicago, Chicago, Illinois., DelDonno SR; Department of Psychiatry & Psychology, University of Illinois at Chicago, Chicago, Illinois., Jenkins LM; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Evanston, Illinois., Easter RE; Department of Psychiatry & Psychology, University of Illinois at Chicago, Chicago, Illinois., Stange JP; Department of Psychiatry & Psychology, University of Illinois at Chicago, Chicago, Illinois; Department of Psychology, University of Southern California, Los Angeles, California., Pocius SL; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Dillahunt A; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Love TM; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Phan KL; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio., Koppelmans V; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Paulus M; Laureate Institute for Brain Research, Tulsa, Oklahoma., Lindquist MA; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Caffo B; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Mickey BJ; Department of Psychiatry, University of Utah, Salt Lake City, Utah., Welsh RC; Department of Psychiatry, University of Utah, Salt Lake City, Utah.
Jazyk: angličtina
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2022 Jan; Vol. 7 (1), pp. 76-84. Date of Electronic Publication: 2021 Jul 13.
DOI: 10.1016/j.bpsc.2021.06.014
Abstrakt: Background: Resting-state graph-based network edges can be powerful tools for identification of mood disorders. We address whether these edges can be integrated with Research Domain Criteria (RDoC) constructs for accurate identification of mood disorder-related markers, while minimizing active symptoms of disease.
Methods: We compared 132 individuals with currently remitted or euthymic mood disorder with 65 healthy comparison participants, ages 18-30 years. Subsets of smaller brain parcels, combined into three prominent networks and one network of parcels overlapping across these networks, were used to compare edge differences between groups. Consistent with the RDoC framework, we evaluated individual differences with performance measure regressors of inhibitory control and reward responsivity. Within an omnibus regression model, we predicted edges related to diagnostic group membership, performance within both RDoC domains, and relevant interactions.
Results: There were several edges of mood disorder group, predominantly of greater connectivity across networks, different than those related to individual differences in inhibitory control and reward responsivity. Edges related to diagnosis and inhibitory control did not align well with prior literature, whereas edges in relation to reward responsivity constructs showed greater alignment with prior literature. Those edges in interaction between RDoC constructs and diagnosis showed a divergence for inhibitory control (negative interactions in default mode) relative to reward (positive interactions with salience and emotion network).
Conclusions: In conclusion, there is evidence that prior simple network models of mood disorders are currently of insufficient biological or diagnostic clarity or that parcel-based edges may be insufficiently sensitive for these purposes.
(Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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