Family history of thyroid disease and risk of congenital hypothyroidism in neonates with Down síndrome.

Autor:	Corona-Rivera JR; Department of Genetics and Cytogenetics Unit, Pediatrics Division, Congenital Anomalies Registration and Research Center, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'.; Department of Molecular Biology and Genomics, Health Sciences University Center, Instituto de Genética Humana 'Dr. Enrique Corona-Rivera', Universidad de Guadalajara., Andrade-Romo TO; Department of Genetics and Cytogenetics Unit, Pediatrics Division, Congenital Anomalies Registration and Research Center, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'., Aguirre-Salas LM; Endocrinology Department, Pediatrics Division, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'., Bobadilla-Morales L; Department of Genetics and Cytogenetics Unit, Pediatrics Division, Congenital Anomalies Registration and Research Center, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'.; Department of Molecular Biology and Genomics, Health Sciences University Center, Instituto de Genética Humana 'Dr. Enrique Corona-Rivera', Universidad de Guadalajara., Aranda-Sánchez CI; Department of Genetics and Cytogenetics Unit, Pediatrics Division, Congenital Anomalies Registration and Research Center, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'., Corona-Rivera A; Department of Genetics and Cytogenetics Unit, Pediatrics Division, Congenital Anomalies Registration and Research Center, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'.; Department of Molecular Biology and Genomics, Health Sciences University Center, Instituto de Genética Humana 'Dr. Enrique Corona-Rivera', Universidad de Guadalajara., Pérez-Ramírez RO; Neonatology Department, Pediatrics Division, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca'. Guadalajara, Jalisco, Mexico.
Jazyk:	angličtina
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2021; Vol. 157 (2), pp. 133-139.
DOI:	10.24875/GMM.M21000538
Abstrakt:	Introduction: Family history of thyroid disease (FHTD) constitutes a possible risk factor for congenital hypothyroidism (CH) in the general population; however, FHTD possible relationship with CH in subjects with Down syndrome (DS) has not yet been explored. Objective: To determine whether FHTD is associated with an increased incidence of CH in neonates with DS. Method: Hospital-based case-control study in 220 neonates with DS. Thyroid function tests of 37 infants with DS and positive FHTD (cases) were compared with those of 183 newborns with DS without FHTD (control group). Data were analyzed using multivariate logistic regression analysis and adjusted odds ratios (aORs) with their respective 95 % confidence intervals (CI) were calculated. Results: Nine newborns with DS in our sample had CH (4.1 %). In the multivariate analysis, FHTD showed an association with CH in neonates with DS (aOR = 8.3, 95 % CI: 2.0-34.3), particularly in males (aOR = 9.0, 95 % CI: 1.6-49.6). In contrast, newborns with DS without FHTD were less likely to suffer from CH (aOR = 0.4, 95 % CI: 0.1-0.8). Conclusions: Newborns with DS and FHTD have an eight-fold higher risk for CH, particularly when the index case is male. FHTD detailed evaluation can be an easy and accessible strategy to identify those newborns with DS at higher risk for CH. (Copyright: © 2021 Permanyer.)
Databáze:	MEDLINE
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