Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport.

Autor: Yan ZJ; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Li YW; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Yang M; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Fu YH; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Wen R; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Wang W; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Li ZT; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Zhang Y; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China., Hou JL; Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Jazyk: angličtina
Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2021 Aug 04; Vol. 143 (30), pp. 11332-11336. Date of Electronic Publication: 2021 Jul 16.
DOI: 10.1021/jacs.1c06000
Abstrakt: We developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. Importantly, this flipping of the channel could lead to their directional alignment in the bilayers and rectifying behavior for ion transport.
Databáze: MEDLINE
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