Clinical significance of prognostic nutrition index in hospitalized patients with COVID-19: Results from single-center experience with systematic review and meta-analysis.

Autor: Rashedi S; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Keykhaei M; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Pazoki M; Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ashraf H; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Najafi A; Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran., Kafan S; Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Peirovi N; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Najmeddin F; Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Jazayeri SA; Department of Medical Laboratory, Tehran University of Medical Sciences, Tehran, Iran., Kashani M; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Moharari RS; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Montazeri M; Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2021 Oct; Vol. 36 (5), pp. 970-983. Date of Electronic Publication: 2021 Jul 16.
DOI: 10.1002/ncp.10750
Abstrakt: Background: We aimed to ascertain risk indicators of in-hospital mortality and severity as well as to provide a comprehensive systematic review and meta-analysis to investigate the prognostic significance of the prognostic nutrition index (PNI) as a predictor of adverse outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients.
Methods: In this cross-sectional study, we studied patients with COVID-19 who were referred to our hospital from February 16 to November 1, 2020. Patients with either a real-time reverse-transcriptase polymerase chain reaction test that was positive for COVID-19 or high clinical suspicion based on the World Health Organization (WHO) interim guidance were enrolled. A parallel systematic review/meta-analysis (in PubMed, Embase, and Web of Science) was performed.
Results: A total of 504 hospitalized COVID-19 patients were included in this study, among which 101 (20.04%) patients died during hospitalization, and 372 (73.81%) patients were categorized as severe cases. At a multivariable level, lower PNI, higher lactate dehydrogenase (LDH), and higher D-dimer levels were independent risk indicators of in-hospital mortality. Additionally, patients with a history of diabetes, lower PNI, and higher LDH levels had a higher tendency to develop severe disease. The meta-analysis indicated the PNI as an independent predictor of in-hospital mortality (odds ratio [OR] = 0.80; P < .001) and disease severity (OR = 0.78; P = .009).
Conclusion: Our results emphasized the predictive value of the PNI in the prognosis of patients with COVID-19, necessitating the implementation of a risk stratification index based on PNI values in hospitalized patients with COVID-19.
(© 2021 American Society for Parenteral and Enteral Nutrition.)
Databáze: MEDLINE
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