Safety of COVID-19 vaccines.

Autor: Al Khames Aga QA; Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan., Alkhaffaf WH; Department of Medicine, Faculty of Medicine, Ninevah University, Mosul, Iraq., Hatem TH; Department of Gynecology, Bagdad Teaching Hospital, Medical City, Baghdad, Iraq., Nassir KF; Department of Gynecology, Bagdad Teaching Hospital, Medical City, Baghdad, Iraq., Batineh Y; Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan., Dahham AT; Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan., Shaban D; Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan., Al Khames Aga LA; COVID-19 Testing Specialist Atechy Group Cardiff, Wales, UK., Agha MYR; Department of Orthopedic Cardiff, University Hospital of Wales, Wales, UK., Traqchi M; Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2021 Dec; Vol. 93 (12), pp. 6588-6594. Date of Electronic Publication: 2021 Jul 28.
DOI: 10.1002/jmv.27214
Abstrakt: This study is aimed to identify the adverse effects associated with three types of coronavirus disease 2019 vaccines. Approximately 1736 individuals agreed to participate in this study. The participants involved in the study were individuals who had received the first dose or full course (two doses) of the vaccine at least 30 days before the survey. A direct and interactive web-based system interview with a paper and electronic version of the questionnaire was used for all participants. A total of 1736 randomized individuals were identified. The reactogenicity of the vaccines including pain, redness, urticaria, and swelling at the site of the injection was reported in 34.56% of the participants. Local site reaction was reported in more individuals who had Pfizer and AstraZeneca vaccines than those who received the Sinopharm vaccine. The systemic events were more common with AstraZeneca and Pfizer vaccines, symptoms reported were fatigue, body pain, headache, muscle pain, fever, and gastrointestinal side effects. There were no correlations between age or gender, and the duration of the adverse effects for the three vaccines. Swelling and severe allergic reaction of the eyelids, severe hypotension, generalized body aches, shortness of breath, weakness and numbness on the injected arm, acute hyperglycemia, severe chest pain, and fever more than 39°C were among the unusual signs and symptoms reported by the participants. Pfizer, AstraZeneca, and Sinopharm vaccines were found to be safe and Sinopharm vaccine showed a lower prevalence of adverse effects compared with the other vaccines. The duration and severity of adverse effects were not affected by age or gender. Unusual side effects should be closely monitored to establish determine they are linked to the immunization.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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