Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

Autor: Ataei A; Orthopaedic Research Lab, Radboud University Medical Center, Radboud Institute for Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. Ali.Ataei@radboudumc.nl., Eggermont F; Orthopaedic Research Lab, Radboud University Medical Center, Radboud Institute for Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Baars M; Orthopaedic Research Lab, Radboud University Medical Center, Radboud Institute for Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., van der Linden Y; Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands., de Rooy J; Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands., Verdonschot N; Orthopaedic Research Lab, Radboud University Medical Center, Radboud Institute for Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.; Laboratory for Biomechanical Engineering, University of Twente, Enschede, The Netherlands., Tanck E; Orthopaedic Research Lab, Radboud University Medical Center, Radboud Institute for Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: International journal of computer assisted radiology and surgery [Int J Comput Assist Radiol Surg] 2021 Oct; Vol. 16 (10), pp. 1841-1849. Date of Electronic Publication: 2021 Jul 15.
DOI: 10.1007/s11548-021-02450-w
Abstrakt: Purpose: Accurate identification of metastatic lesions is important for improvement in biomechanical models that calculate the fracture risk of metastatic bones. The aim of this study was therefore to assess the inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.
Methods: CT scans of 54 metastatic femurs (19 osteolytic, 17 osteoblastic, and 18 mixed) were segmented two times by two operators. Dice coefficients (DCs) were calculated adopting the quantification that a DC˃0.7 indicates good reliability.
Results: Generally, rather poor inter- and intra-operator reliability of lesion segmentation were found. Inter-operator DCs were 0.54 (± 0.28) and 0.50 (± 0.32) for the first and second segmentations, respectively, whereas intra-operator DCs were 0.56 (± 0.28) for operator I and 0.71 (± 0.23) for operator II. Larger lesions scored significantly higher DCs in comparison with smaller lesions. Of the femurs with larger mean segmentation volumes, 83% and 93% were segmented with good inter- and intra-operator DCs (> 0.7), respectively. There was no difference between the mean DCs of osteolytic, osteoblastic, and mixed lesions.
Conclusion: Manual segmentation of femoral bone metastases is very challenging and resulted in unsatisfactory mean reliability values. There is a need for development of a segmentation protocol to reduce the inter- and intra-operator segmentation variation as the first step and use of computer-assisted segmentation tools as a second step as this study shows that manual segmentation of femoral metastatic lesions is highly challenging.
(© 2021. The Author(s).)
Databáze: MEDLINE
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