Platelet lysate for COVID-19 pneumonia-a newer adjunctive therapeutic avenue.

Autor:	Jeyaraman M; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Orthopedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.; Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India., Muthu S; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India.; Department of Orthopedics, Government Medical College & Hospital, Dindigul, Tamil Nadu, India., Khanna M; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Orthopedics, Prasad Institute of Medical Science and Hospital, Lucknow, Uttar Pradesh, India., Jain R; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India., Anudeep TC; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Plastic Surgery, Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai, Maharashtra, India., Muthukanagaraj P; Department of Internal Medicine & Psychiatry, SUNY-Upstate Binghamton Clinical Campus, Binghamton, New York, USA., Siddesh SE; Department of Dermatology, Raja Rajeswari Medical College & Hospital, Bengaluru, Karnataka, India., Gulati A; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Orthopedics, Kalpana Chawla Government Medical College & Hospital, Karnal, Haryana, India., Satish AS; Department of Orthopedics, Sri Devaraj URS Medical College, Kolar, Karnataka, India., Jeyaraman N; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Orthopedics, Kasturba Medical College, MAHE Unievrsity, Manipal, Karnataka, India., Khanna V; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India.; Department of Pathology, Prasad Institute of Medical Science and Hospital, Lucknow, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	Stem cell investigation [Stem Cell Investig] 2021 Jun 08; Vol. 8, pp. 11. Date of Electronic Publication: 2021 Jun 08 (Print Publication: 2021).
DOI:	10.21037/sci-2020-042
Abstrakt:	The linchpin for COVID-19 pathogenesis is the severe inflammatory process in the respiratory tract wherein the accumulation of excessive cytokines paves the way for a series of systemic hemodynamic alterations and mortality. The mortality rate is higher in individuals with co-morbidities and advancing age. The absence of a specific therapy is responsible for this uncontrolled spread and the significant mortality. This renders potential insight for considering biologics as a plausible option to repair and regenerate the affected lung tissue and pulverize the causative organism. The plausible role of megakaryocytes against invading microbes was not clearly understood. Platelet lysate is an acellular product consisting of regenerative molecules released from a cluster of platelets. It attenuates the changes caused by immune reactions in allogenic utility with the introduction of growth factors, cytokines, and proteins at supraphysiologic levels and thereby serves as a regenerative immunomodulatory agent to combat COVID-19. This platelet lysate can be used in nebulized form for such acute respiratory distress conditions in COVID-19 elderly patients. Platelet lysate may emerge as a pivotal player provided investigations pace up in this context. Here, we discuss how the platelet lysate can plausibly perquisite to relegate COVID-19. Undertaking prospective randomized controlled trials to prove its efficacy is the need of the hour in this pandemic scenario. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/sci-2020-042). The authors have no conflicts of interest to declare. (2021 Stem Cell Investigation. All rights reserved.)
Databáze:	MEDLINE
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