Perspective: Moving Toward Desirable Linoleic Acid Content in Infant Formula.

Autor:	Carlson SE; Department of Dietetics and Nutrition, Kansas University Medical Center, Kansas City, KS, USA., Schipper L; Danone Nutricia Research, Utrecht, The Netherlands., Brenna JT; Department of Pediatrics, University of Texas at Austin, Austin, TX, USA.; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA., Agostoni C; Pediatric Area, Fondazione IRCCS Ca'Granda- Ospedale Maggiore Policlinico, Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Calder PC; Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Forsyth S; University of Dundee, West Ferry, Dundee, United Kingdom., Legrand P; Laboratoire de Biochimie-Nutrition Humaine, Agrocampus-French National Institute of Health and Medical Research, Rennes, France., Abrahamse-Berkeveld M; Danone Nutricia Research, Utrecht, The Netherlands., van de Heijning BJM; Danone Nutricia Research, Utrecht, The Netherlands., van der Beek EM; Danone Nutricia Research, Utrecht, The Netherlands.; Department of Pediatrics, University Medical Center, Groningen, The Netherlands., Koletzko BV; Ludwig-Maximilians-Universität Munich, Department of Paediatrics, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Muhlhausler B; Nutrition and Health Program, Health and Biosecurity, CSIRO, Adelaide, Australia.; School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia.
Jazyk:	angličtina
Zdroj:	Advances in nutrition (Bethesda, Md.) [Adv Nutr] 2021 Dec 01; Vol. 12 (6), pp. 2085-2098.
DOI:	10.1093/advances/nmab076
Abstrakt:	Infant formula should provide the appropriate nutrients and adequate energy to facilitate healthy infant growth and development. If conclusive data on quantitative nutrient requirements are not available, the composition of human milk (HM) can provide some initial guidance on the infant formula composition. This paper provides a narrative review of the current knowledge, unresolved questions, and future research needs in the area of HM fatty acid (FA) composition, with a particular focus on exploring appropriate intake levels of the essential FA linoleic acid (LA) in infant formula. The paper highlights a clear gap in clinical evidence as to the impact of LA levels in HM or formula on infant outcomes, such as growth, development, and long-term health. The available preclinical information suggests potential disadvantages of high LA intake in the early postnatal period. We recommend performing well-designed clinical intervention trials to create clarity on optimal levels of LA to achieve positive impacts on both short-term growth and development and long-term functional health outcomes. (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
Databáze:	MEDLINE
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