Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats.

Autor: Mahmoudi F; Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, 5619913131, Ardabil, Iran. f.mahmoudi@uma.ac.ir., Mahmoudi F; Department of Chemistry, Shahid Beheshti University, G. C., 1983963113, Tehran, Iran. fa_mahmoudi@sbu.ac.ir., Gollo KH; Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, 5619913131, Ardabil, Iran., Amini MM; Department of Chemistry, Shahid Beheshti University, G. C., 1983963113, Tehran, Iran.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2022 May; Vol. 200 (5), pp. 2223-2232. Date of Electronic Publication: 2021 Jul 15.
DOI: 10.1007/s12011-021-02819-7
Abstrakt: In this work, we synthesized and reported gold nanoparticles (Au NPs) with Eryngium thyrsoideum Boiss plant extract for first time. The plant extract has important effect as reducing and stabilizing agent for preparation of Au nanoparticles. The synthesized gold nanoparticles were characterized with FT-IR, UV-vis, XRD, SEM, and TEM analyses. All analyses confirmed successful synthesis of gold nanoparticles with high purity. The antidiabetic activity of synthesized Au NPs was investigated on type 2 diabetic rats by studying their influences on serum biochemical parameters and inflammatory markers. Obtained results revealed that hepatic enzymes, TNF-α, and interleukin-6 of diabetic rats receiving gold nanoparticles decreased in compare with healthy control rats. As inflammatory markers are main reasons for hyperglycemic-induced insulin resistance in diabetes, Au NPs have a possible option for management of the diabetes-related complication via their potent anti-inflammatory and hypoglycemic effects.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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