Self-reported periodontal health and incident hypertension: longitudinal evidence from the NutriNet-Santé e-cohort.

Autor: Carra MC; Department of Periodontology, U.F.R. d'Odontologie-Garanciere, Université de Paris, Paris and Rothschild Hospital (AP-HP), Paris.; Inserm, Population-based Epidemiologic Cohorts Unit, UMS 011, Villejuif., Fessi S; Department of Periodontology, U.F.R. d'Odontologie-Garanciere, Université de Paris, Paris and Rothschild Hospital (AP-HP), Paris., Detzen L; Department of Periodontology, U.F.R. d'Odontologie-Garanciere, Université de Paris, Paris and Rothschild Hospital (AP-HP), Paris., Darnaud C; Department of Periodontology, U.F.R. d'Odontologie-Garanciere, Université de Paris, Paris and Rothschild Hospital (AP-HP), Paris.; INSERM U970, Pharmacology Department, Georges Pompidou European Hospital, Paris., Julia C; Sorbonne Paris Nord University/Inserm/Inrae/Cnam, Nutritional Epidemiology Research Group (EREN), Epidemiology and Statistics Research Center - University of Paris (CRESS).; Public Health Department, Paris Seine-Saint-Denis Hospitals (AP-HP), Bobigny., Hercberg S; Sorbonne Paris Nord University/Inserm/Inrae/Cnam, Nutritional Epidemiology Research Group (EREN), Epidemiology and Statistics Research Center - University of Paris (CRESS)., Touvier M; Sorbonne Paris Nord University/Inserm/Inrae/Cnam, Nutritional Epidemiology Research Group (EREN), Epidemiology and Statistics Research Center - University of Paris (CRESS)., Andreeva VA; Sorbonne Paris Nord University/Inserm/Inrae/Cnam, Nutritional Epidemiology Research Group (EREN), Epidemiology and Statistics Research Center - University of Paris (CRESS)., Bouchard P; Department of Periodontology, U.F.R. d'Odontologie-Garanciere, Université de Paris, Paris and Rothschild Hospital (AP-HP), Paris.; EA 2496, U.F.R. d'Odontologie-Montrouge, Université de Paris, Paris, France.
Jazyk: angličtina
Zdroj: Journal of hypertension [J Hypertens] 2021 Dec 01; Vol. 39 (12), pp. 2422-2430.
DOI: 10.1097/HJH.0000000000002941
Abstrakt: Objective: An association between periodontitis and arterial hypertension has been suggested recently. This study aimed at investigating the hypothesis that periodontal health is linked to incident arterial hypertension.
Methods: We analyzed data from the French population-based e-cohort NutriNet-Santé, selecting participants who had completed two oral health questionnaires in 2011-2012. Pregnant women, participants with diabetes, cancer, arterial hypertension and cardiovascular diseases at inclusion were excluded. Incident cases of arterial hypertension were self-reported and/or based on the use of antihypertensive therapy. Periodontal health was evaluated by estimating the modified and validated PEriodontal Screening Score (mPESS), with mPESS at least 5 corresponding to a high probability of severe periodontitis. Descriptive statistics and Cox proportional hazards regression models, taking into account sociodemographic and lifestyle confounders, were used.
Results: The study population consisted of 32 285 participants (mean age: 45.79 ± 13.87 years); 78.5% were women. Two thousand one hundred and sixteen incident cases of arterial hypertension were identified during a median follow-up of 8 years (April 2012--December 2019). In the fully adjusted model, an mPESS at least 5 [hazard ratio: 1.84; 95% confidence interval (CI): 1.66-2.03] and the presence of nonreplaced missing teeth (hazard ratio: 1.13; 95% CI: 1.03-1.23) were significantly associated with a greater risk of incident arterial hypertension, whereas a regular annual visit to the dentist was associated with a lower risk (hazard ratio: 0.88; 95% CI: 0.80-0.97).
Conclusion: Self-reported assessed periodontitis was associated with incident arterial hypertension over an 8-year period. The present results highlight the importance of considering periodontal health when assessing an individual's risk of arterial hypertension.
Trial Registration: # NCT03335644.
(Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze: MEDLINE
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