Impact of severe SARS-CoV-2 infection on nutritional status and subjective functional loss in a prospective cohort of COVID-19 survivors.

Autor:	Quilliot D; Unité Transversale de Nutrition, CHRU de Nancy, Nancy, France d.quilliot@chru-nancy.fr., Gérard M; Unité Transversale de Nutrition, CHRU de Nancy, Nancy, France., Bonsack O; Unité Transversale de Nutrition, CHRU de Nancy, Nancy, France., Malgras A; Unité Transversale de Nutrition, CHRU de Nancy, Nancy, France., Vaillant MF; Université Grenoble Alpes, Saint-Martin-d'Heres, France., Di Patrizio P; General Medicine Department, University of Lorraine, Nancy, France., Jaussaud R; Internal Medicine and Clinical Immunology Department, CHRU de Nancy, Nancy, France., Ziegler O; Endocrinology Diabetology and Nutrition Department, CHRU de Nancy, Nancy, France., Nguyen-Thi PL; Medical Evaluation Department, Department of Clinical Research Support PARC, University of Lorraine, CHRU de Nancy, Nancy, France.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2021 Jul 14; Vol. 11 (7), pp. e048948. Date of Electronic Publication: 2021 Jul 14.
DOI:	10.1136/bmjopen-2021-048948
Abstrakt:	The nutritional sequelae of COVID-19 have not been explored in a large cohort study. Objectives: To identify factors associated with the change in nutritional status between discharge and 30 days post-discharge (D30). Secondary objectives were to determine the prevalence of subjective functional loss and severe disability at D30 and their associated factors. Methods: Collected data included symptoms, nutritional status, self-evaluation of food intake, Performance Status (PS) Scale, Asthenia Scale, self-evaluation of strength (SES) for arms and legs at discharge and at D30. An SES <7 was used to determine subjective functional loss. A composite criteria for severe disability was elaborated combining malnutrition, subjective functional loss and PS >2. Patients were classified into three groups according to change in nutritional status between discharge and D30 (persistent malnutrition, correction of malnutrition and the absence of malnutrition). Results: Of 549 consecutive patients hospitalised for COVID-19 between 1 March and 29 April 2020, 130 died including 17 after discharge (23.7%). At D30, 312 patients were at home, 288 (92.3%) of whom were interviewed. Of the latter, 33.3% were malnourished at discharge and still malnourished at D30, while 23.2% were malnourished at discharge but no longer malnourished at D30. The highest predictive factors of persistent malnutrition were intensive care unit (ICU) stay (OR=3.42, 95% CI: 2.04 to 5.75), subjective functional loss at discharge (OR=3.26, 95% CI: 1.75 to 6.08) and male sex (OR=2.39, 95% CI: 1.44 to 3.97). Subjective functional loss at discharge (76.8%) was the main predictive factor of subjective functional loss at D30 (26.3%) (OR=32.6, 95% CI: 4.36 to 244.0). Lastly, 8.3% had a severe disability, with a higher risk in patients requiring an ICU stay (OR=3.39, 95% CI: 1.43 to 8.06). Conclusion: Patients who survived a severe form of COVID-19 had a high risk of persistent malnutrition, functional loss and severe disability at D30. We believe that nutritional support and rehabilitation should be strengthened, particularly for male patients who were admitted in ICU and had subjective functional loss at discharge. Trial Registration Number: NCT04451694. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu