Comorbidities of primary headache disorders: a literature review with meta-analysis.

Autor: Caponnetto V; SS Filippo & Nicola Hospital , University of L'Aquila, Avezzano, Italy. valeria.caponnetto@univaq.it., Deodato M; Department of Life Sciences, University of Trieste, Trieste, Italy. mdeodato@units.it.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. mdeodato@units.it., Robotti M; Centro di Diagnosi e Cura delle Cefalee, Palazzo della Salute, Gruppo San Donato, Milano, Italy.; PainClinicMilano, Centro Medico Visconti di Modrone, Milano, Italy., Koutsokera M; Thriassio General Hospital of Elefsina, Elefsina, Greece., Pozzilli V; Internal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy., Galati C; UO Neuropsichiatria Infantile, Policlinico Universitario Paolo Giaccone, Università degli Studi di Palermo, Palermo, Italy., Nocera G; UO Neuropsichiatria Infantile, Policlinico Universitario Paolo Giaccone, Università degli Studi di Palermo, Palermo, Italy., De Matteis E; Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy., De Vanna G; Clinica Neurologica, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy., Fellini E; Internal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy., Halili G; Department of Neurology, University Hospital Center 'Mother Teresa', Tirana, Albania., Martinelli D; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Nalli G; Internal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy., Serratore S; Internal Medicine Unit, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy., Tramacere I; Dipartimento di Ricerca e Sviluppo Clinico, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy., Martelletti P; Department of Clinical and Molecular Medicine, Sapienza University, Roma, Italy.; Regional Referral Headache Center, Sant'Andrea University Hospital, Roma, Italy., Raggi A; UOC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Jazyk: angličtina
Zdroj: The journal of headache and pain [J Headache Pain] 2021 Jul 14; Vol. 22 (1), pp. 71. Date of Electronic Publication: 2021 Jul 14.
DOI: 10.1186/s10194-021-01281-z
Abstrakt: Background: Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headache disorders using a meta-analytical approach based on studies published between 2000 and 2020.
Methods: Scopus was searched for primary research (clinical and population studies) in which medical comorbidities were described in adults with primary headache disorders. Comorbidities were extracted using a taxonomy derived from the Global Burden of Disease (GBD) study. We compared prevalence of comorbidities among headache sufferers against general population using GBD-2019 estimates, and compared comorbidities' proportions in clinical vs. population studies, and by age and gender.
Results: A total of 139 studies reporting information on 4.19 million subjects with primary headaches were included: in total 2.75 million comorbidities were reported (median per subject 0.64, interquartile range 0.32-1.07). The most frequently addressed comorbidities were: depressive disorders, addressed in 51 studies (pooled proportion 23 %, 95 % CI 20-26 %); hypertension, addressed in 48 studies (pooled proportion 24 %, 95 % CI 22-26 %); anxiety disorders addressed in 40 studies (pooled proportion 25 %, 95 % CI 22-28 %). For conditions such as anxiety, depression and back pain, prevalence among headache sufferers was higher than in GBD-2109 estimates. Associations with average age and female prevalence within studies showed that hypertension was more frequent in studies with higher age and less females, whereas fibromyalgia, restless leg syndrome, and depressive disorders were more frequent in studies with younger age and more female.
Conclusions: Some of the most relevant comorbidities of primary headache disorders - back pain, anxiety and depression, diabetes, ischemic heart disease and stroke - are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers' health status and contribute to reduce the impact of a group of highly burdensome diseases.
(© 2021. The Author(s).)
Databáze: MEDLINE