Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders.

Autor: Sirica D; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA., Hewitt AL; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA.; Division of Child Neurology, Department of Neurology, University of Rochester, Rochester, NY 14623, USA., Tarolli CG; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA.; Center for Health & Technology (CHeT), University of Rochester, Rochester, NY 14642, USA., Weber MT; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA., Zimmerman C; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA., Santiago A; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA., Wensel A; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA.; Department of Neurosurgery, University of Rochester, Rochester, NY 14618, USA., Mink JW; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA.; Division of Child Neurology, Department of Neurology, University of Rochester, Rochester, NY 14623, USA., Lizárraga KJ; Motor Physiology & Neuromodulation Program, Division of Movement Disorders, Department of Neurology, University of Rochester, Rochester, NY 14618, USA.; Center for Health & Technology (CHeT), University of Rochester, Rochester, NY 14642, USA.
Jazyk: angličtina
Zdroj: Neurodegenerative disease management [Neurodegener Dis Manag] 2021 Aug; Vol. 11 (4), pp. 315-328. Date of Electronic Publication: 2021 Jul 15.
DOI: 10.2217/nmt-2021-0002
Abstrakt: Intraoperative neurophysiological information could increase accuracy of surgical deep brain stimulation (DBS) lead placement. Subsequently, DBS therapy could be optimized by specifically targeting pathological activity. In Parkinson's disease, local field potentials (LFPs) excessively synchronized in the beta band (13-35 Hz) correlate with akinetic-rigid symptoms and their response to DBS therapy, particularly low beta band suppression (13-20 Hz) and high frequency gamma facilitation (35-250 Hz). In dystonia, LFPs abnormally synchronize in the theta/alpha (4-13 Hz), beta and gamma (60-90 Hz) bands. Phasic dystonic symptoms and their response to DBS correlate with changes in theta/alpha synchronization. In essential tremor, LFPs excessively synchronize in the theta/alpha and beta bands. Adaptive DBS systems will individualize pathological characteristics of neurophysiological signals to automatically deliver therapeutic DBS pulses of specific spatial and temporal parameters.
Databáze: MEDLINE