Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria.

Autor:	Moses DA; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Metzger SL; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Liu JR; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Anumanchipalli GK; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Makin JG; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Sun PF; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Chartier J; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Dougherty ME; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Liu PM; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Abrams GM; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Tu-Chan A; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Ganguly K; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.)., Chang EF; From the Department of Neurological Surgery (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., M.E.D., E.F.C.), the Weill Institute for Neuroscience (D.A.M., S.L.M., J.R.L., G.K.A., J.G.M., P.F.S., J.C., K.G., E.F.C.), and the Departments of Rehabilitation Services (P.M.L.) and Neurology (G.M.A., A.T.-C., K.G.), University of California, San Francisco (UCSF), San Francisco, and the Graduate Program in Bioengineering, University of California, Berkeley-UCSF, Berkeley (S.L.M., J.R.L., E.F.C.).
Jazyk:	angličtina
Zdroj:	The New England journal of medicine [N Engl J Med] 2021 Jul 15; Vol. 385 (3), pp. 217-227.
DOI:	10.1056/NEJMoa2027540
Abstrakt:	Background: Technology to restore the ability to communicate in paralyzed persons who cannot speak has the potential to improve autonomy and quality of life. An approach that decodes words and sentences directly from the cerebral cortical activity of such patients may represent an advancement over existing methods for assisted communication. Methods: We implanted a subdural, high-density, multielectrode array over the area of the sensorimotor cortex that controls speech in a person with anarthria (the loss of the ability to articulate speech) and spastic quadriparesis caused by a brain-stem stroke. Over the course of 48 sessions, we recorded 22 hours of cortical activity while the participant attempted to say individual words from a vocabulary set of 50 words. We used deep-learning algorithms to create computational models for the detection and classification of words from patterns in the recorded cortical activity. We applied these computational models, as well as a natural-language model that yielded next-word probabilities given the preceding words in a sequence, to decode full sentences as the participant attempted to say them. Results: We decoded sentences from the participant's cortical activity in real time at a median rate of 15.2 words per minute, with a median word error rate of 25.6%. In post hoc analyses, we detected 98% of the attempts by the participant to produce individual words, and we classified words with 47.1% accuracy using cortical signals that were stable throughout the 81-week study period. Conclusions: In a person with anarthria and spastic quadriparesis caused by a brain-stem stroke, words and sentences were decoded directly from cortical activity during attempted speech with the use of deep-learning models and a natural-language model. (Funded by Facebook and others; ClinicalTrials.gov number, NCT03698149.). (Copyright © 2021 Massachusetts Medical Society.)
Databáze:	MEDLINE
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