Functional hypogonadism in middle-aged and older men: testosterone treatment or not?

Autor: Grossmann M; Department of Medicine, Austin Health, The University of Melbourne, Victoria, Australia.; Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia., Jones TH; Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK.; Department of Oncology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.
Jazyk: angličtina
Zdroj: European journal of endocrinology [Eur J Endocrinol] 2021 Aug 03; Vol. 185 (3), pp. D1-D9. Date of Electronic Publication: 2021 Aug 03.
DOI: 10.1530/EJE-21-0362
Abstrakt: Clinicians commonly encounter middle-aged and older men who present with functional hypogonadism, that is, with clinical features compatible with androgen deficiency and lowered serum testosterone, but without evidence of organic hypothalamic-pituitary-testicular axis pathology. Whether, and when, testosterone therapy should be offered to such men remains uncertain and controversial, in part due to the lack of definitive evidence regarding long-term patient-important health outcomes with testosterone treatment. In this debate, we address this controversy and provide two opposing points of view on the role of testosterone treatment in older men with functional hypogonadism.
Databáze: MEDLINE