Mechanism of a Disassembly-Driven Sensing System Studied by Stopped-Flow Kinetics.

Autor:	Gallo C; Department of Chemistry and Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, P.O. Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada., Thomas SS; Department of Chemistry and Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, P.O. Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada., Selinger AJ; Department of Chemistry and Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, P.O. Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada., Hof F; Department of Chemistry and Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, P.O. Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada., Bohne C; Department of Chemistry and Centre for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, P.O. Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of organic chemistry [J Org Chem] 2021 Aug 06; Vol. 86 (15), pp. 10782-10787. Date of Electronic Publication: 2021 Jul 14.
DOI:	10.1021/acs.joc.1c00959
Abstrakt:	We carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined. Relative rates for these competing processes provide insight on how this system can be optimized for sensing applications. Kinetics studies in artificial saliva showed that moving to more complex media has minimal effects on the sensing ability of the system.
Databáze:	MEDLINE
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