Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study.

Autor: De Santis V; Department of Anesthesia and Intensive Care Medicine, Ospedale Santa Maria Delle Croci, Viale Randi, 5, 48121, Ravenna, Italy. vincenzo.desantis@auslromagna.it., Corona A; Emergency Anesthesia and Intensive Care Medicine Department, Esine and Edolo Hospital, ASST Valcamonica, Brescia, Italy., Vitale D; Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy., Nencini C; Department of Anesthesia and Intensive Care Medicine, Ospedale Santa Maria Delle Croci, Viale Randi, 5, 48121, Ravenna, Italy., Potalivo A; Department of Anesthesia and Intensive Care Medicine, Ospedale 'Infermi' Rimini, Rimini, Italy., Prete A; Department of Anesthesia and Intensive Care Medicine, Ospedale Santa Maria Delle Croci, Viale Randi, 5, 48121, Ravenna, Italy., Zani G; Department of Anesthesia and Intensive Care Medicine, Ospedale Santa Maria Delle Croci, Viale Randi, 5, 48121, Ravenna, Italy., Malfatto A; Department of Anesthesia and Intensive Care Medicine, Ospedale di Bentivoglio Azienda USL Bologna, Bologna, Italy., Tritapepe L; Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy., Taddei S; Department of Anesthesia and Intensive Care Medicine, Ospedale di Bentivoglio Azienda USL Bologna, Bologna, Italy., Locatelli A; Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy., Sambri V; UOC Microbiology and Medical Laboratory, AUSL Romagna, Cesena, Italy., Fusari M; Department of Anesthesia and Intensive Care Medicine, Ospedale Santa Maria Delle Croci, Viale Randi, 5, 48121, Ravenna, Italy., Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.
Jazyk: angličtina
Zdroj: Infection [Infection] 2022 Feb; Vol. 50 (1), pp. 139-148. Date of Electronic Publication: 2021 Jul 14.
DOI: 10.1007/s15010-021-01661-2
Abstrakt: Purpose: To investigate the prevalence, incidence and characteristics of bacterial infections and their impact on outcome in critically ill patients infected with COVID-19.
Methods: We conducted a prospective observational study in eight Italian ICUs from February to May 2020; data were collected through an interactive electronic database. Kaplan-Meier analysis (limit product method) was used to identify the occurrence of infections and risk of acquisition.
Results: During the study period 248 patients were recruited in the eight participating ICUs. Ninety (36.3%) patients developed at least one episode of secondary infection. An ICU length of stay between 7 and 14 days was characterized by a higher occurrence of infectious complications, with ventilator-associated pneumonia being the most frequent. At least one course of antibiotic therapy was given to 161 (64.9%) patients. Overall ICU and hospital mortality were 33.9% and 42.9%, respectively. Patients developing bacteremia had a higher risk of ICU mortality [45.9% vs. 31.6%, odds ratio 1.8 (95% CI 0.9-3.7), p = 0.069] and hospital mortality [56.8% vs. 40.3%, odds ratio 1.9 (95% CI 1.1-3.9), p = 0.04].
Conclusion: In critically ill patients infected with COVID-19 the incidence of bacterial infections is high and associated with worse outcomes. Regular microbiological surveillance and strict infection control measures are mandated.
(© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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