Reduction of heart and lung normal tissue complication probability using automatic beam angle optimization and more generic optimization objectives for breast radiotherapy.

Autor:	Bakx N; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., Bluemink H; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., Hagelaar E; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., van der Leer J; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., van der Sangen M; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., Theuws J; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands., Hurkmans C; Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands.
Jazyk:	angličtina
Zdroj:	Physics and imaging in radiation oncology [Phys Imaging Radiat Oncol] 2021 Apr 28; Vol. 18, pp. 48-50. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021).
DOI:	10.1016/j.phro.2021.04.002
Abstrakt:	During breast cancer radiotherapy, sparing of healthy tissue is desired. The effect of automatic beam angle optimization and generic dose fall-off objectives on dose and normal tissue complication probabilities was studied. In all patients, dose to lungs and heart showed a mean reduction of 0.4 Gy (range 0.1-1.3 Gy) and 0.2 Gy (range -0.2-0.7 Gy), respectively. These lower doses led to a statistically significant lower cumulative cardiac and lung cancer mortality risk. For smoking patients 40-45 years of age who continue to smoke, it would lead to a reduction from 3.2% ± 0.7% to 2.7% ± 0.6% (p < 0.001). Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).)
Databáze:	MEDLINE
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