Anti-Inflammatory Activity of Artemisia vulgaris Leaves, Originating from Three Different Altitudes of Nepal.

Autor: Pandey J; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Bhusal S; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Nepali L; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Khatri M; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Ramdam R; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Barakoti H; Department of Pharmacy, Purbanchal University, Biratnagar 56613, Nepal., Giri PM; Siddhartha Pharmaceutical Private Limited, Rupandehi 32900, Nepal., Pant D; Department of Medical Laboratory Science, School of Health and Allied Sciences, Pokhara University, Pokhara 33370, Nepal., Aryal P; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal., Rokaya RK; Department of Pharmacology, Karnali Academy of Health Science, Jumla, Chandannath 21200, Nepal., Bhandari R; Department of Pharmacy, Crimson College of Technology, Affiliated to Pokhara University, Butwal, Rupandehi 32900, Nepal.
Jazyk: angličtina
Zdroj: TheScientificWorldJournal [ScientificWorldJournal] 2021 Jun 22; Vol. 2021, pp. 6678059. Date of Electronic Publication: 2021 Jun 22 (Print Publication: 2021).
DOI: 10.1155/2021/6678059
Abstrakt: This study aimed to evaluate and compare the in vivo chronic anti-inflammatory efficacy, from the ethyl acetate and ethanolic extracts of Artemisia vulgaris leaves, grown at three different altitudes in Nepal, by formalin-induced paw edema in Swiss albino mice. Edema was induced on the mice paw by administering 0.2% of formalin injection. Indomethacin was used as a standard drug at the concentration of 5 mg/kg of body weight. Ethyl acetate and ethanolic leaves extract, at the concentration of 200 mg/kg and 400 mg/kg, were used as test drugs. Standard drug and all the extracts were administered 30 min before formalin injection. The paw thickness was measured at 0, 1, 2, 3, 24, 48, and 72 hours after formalin injection, using a Vernier caliper. It was observed that both ethyl acetate and ethanolic extract from all the altitudes exhibited significant inhibition of paw edema ( p < 0.05) induced by formalin. Maximum activity was shown by 400 mg/kg of the plant leaf extract taken from the temperate zone, with 54.05% of paw edema inhibition, and it is almost similar to the inhibition of standard drug (56.75%). Moreover, the ethanolic extract was found to be more effective than ethyl acetate extract in all the plant samples. The results suggested that the anti-inflammatory effect of A. vulgaris leaves increases with an increase in altitudes and this plant can be used as a useful source of medicine to treat chronic inflammation.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Jitendra Pandey et al.)
Databáze: MEDLINE
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