Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal.

Autor: Sai K; Department of Pharmaceutical Sciences, School of Health and Allied Sciences, Pokhara University, Pokhara 33700, Nepal., Chhetri SBB; Department of Pharmaceutical Sciences, School of Health and Allied Sciences, Pokhara University, Pokhara 33700, Nepal., Devkota SR; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia., Khatri D; Department of Pharmaceutical Sciences, School of Health and Allied Sciences, Pokhara University, Pokhara 33700, Nepal.
Jazyk: angličtina
Zdroj: TheScientificWorldJournal [ScientificWorldJournal] 2021 Jun 25; Vol. 2021, pp. 3230351. Date of Electronic Publication: 2021 Jun 25 (Print Publication: 2021).
DOI: 10.1155/2021/3230351
Abstrakt: Spondias pinnata (L.f.) Kurz. (family: Anacardiaceae) is a wild deciduous tree indigenous to southeast Asian countries. Different parts of this plant are used traditionally for the treatment and cure of various disorders and illnesses. S. pinnata leaves are used to prevent and treat diabetes in traditional Balinese medicine. However, scientific study on the antihyperglycemic effect of its leaves has not been reported yet. Therefore, this study aims to perform phytochemical screening and investigate the hypoglycemic potential of S. pinnata leaves extract. Preliminary phytochemical screening of the hydroethanolic extract was performed following the standard tests. In vivo hypoglycemic activity of the leaves extract was evaluated using normal and glucose-loaded rats. The results displayed the presence of phytochemical constituents such as saponins, phenolic compounds, flavonoids, and terpenoids. S. pinnata (500 mg/kg) and metformin (100 mg/kg) exhibited a significant ( p < 0.05) decrease in blood glucose level at 1, 2, and 3 h in normal rats when compared to the control group. Metformin- (100 mg/kg)- and S. pinnata- (500 mg/kg)- treated groups showed a maximum decrease in the blood glucose level at 3 h after single-dose administration in the oral glucose tolerance test (OGTT). In conclusion, S. pinnata leaves possess a significant hypoglycemic activity in the animal model and thus support its traditional use to treat diabetes. Therefore, a detailed mechanism-based study and isolation of bioactive compounds from S. pinnata leaves would be beneficial in the future for the search of new hypoglycemic agents.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2021 Kusum Sai et al.)
Databáze: MEDLINE
Externí odkaz: