Gut-microbiota-targeted diets modulate human immune status.

Autor:	Wastyk HC; Department of Bioengineering, Stanford School of Medicine, Stanford, CA 94305, USA., Fragiadakis GK; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Perelman D; Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Dahan D; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Merrill BD; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Yu FB; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Topf M; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Gonzalez CG; Department of Chemical and Systems Biology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA., Van Treuren W; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Han S; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA., Robinson JL; Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Elias JE; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Sonnenburg ED; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA; Center for Human Microbiome Studies, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: erica.sonnenburg@stanford.edu., Gardner CD; Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA. Electronic address: cgardner@stanford.edu., Sonnenburg JL; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA; Center for Human Microbiome Studies, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: jsonnenburg@stanford.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 Aug 05; Vol. 184 (16), pp. 4137-4153.e14. Date of Electronic Publication: 2021 Jul 12.
DOI:	10.1016/j.cell.2021.06.019
Abstrakt:	Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence the human microbiome and immune system in healthy adults. Using a 17-week randomized, prospective study (n = 18/arm) combined with -omics measurements of microbiome and host, including extensive immune profiling, we found diet-specific effects. The high-fiber diet increased microbiome-encoded glycan-degrading carbohydrate active enzymes (CAZymes) despite stable microbial community diversity. Although cytokine response score (primary outcome) was unchanged, three distinct immunological trajectories in high-fiber consumers corresponded to baseline microbiota diversity. Alternatively, the high-fermented-food diet steadily increased microbiota diversity and decreased inflammatory markers. The data highlight how coupling dietary interventions to deep and longitudinal immune and microbiome profiling can provide individualized and population-wide insight. Fermented foods may be valuable in countering the decreased microbiome diversity and increased inflammation pervasive in industrialized society. Competing Interests: Declaration of interests H.C.W. is a founder and shareholder of Interface Biosciences. W.V.T. is a founder and shareholder of Interface Biosciences. J.L.S. is a founder, shareholder, and on the scientific advisory board of January AI and Novome Biotechnologies. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu