Cross-Sectional Assessment of SARS-CoV-2 Viral Load by Symptom Status in Massachusetts Congregate Living Facilities.

Autor:	Lennon NJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA., Bhattacharyya RP; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Massachusetts General Hospital, Boston, Massachusetts, USA., Mina MJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Rehm HL; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Massachusetts General Hospital, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Hung DT; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Massachusetts General Hospital, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Smole S; State Public Health Laboratory, Massachusetts Department of Public Health, Boston, Massachusetts, USA., Woolley A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA., Lander ES; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gabriel SB; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2021 Nov 22; Vol. 224 (10), pp. 1658-1663.
DOI:	10.1093/infdis/jiab367
Abstrakt:	Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12-38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu