Synthesis of 2,3,4-Trisubstituted 2-Cyclopentenones via Sequential Functionalization of 2-Cyclopentenone.
| Autor: | Gowala TN; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110., Chaudhari P; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110., Pabba J; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110., Sawant K; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110., Pal S; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110., Ghorai SK; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2021 Aug 06; Vol. 86 (15), pp. 10812-10818. Date of Electronic Publication: 2021 Jul 13. |
| DOI: | 10.1021/acs.joc.1c01039 |
| Abstrakt: | The synthesis of differently substituted 2,3,4-triarylcyclopent-2-en-1-ones from 2-cyclopentenone via sequential functionalization of a novel 2,4-dibromo-3-(4-methoxyphenyl) cyclopent-2-en-1-one intermediate has been developed. The process provides access to selective arylation at C-4 and C-2 with a broader substrates scope, which includes heteroaryl and alkyl substitution at C-2. |
| Databáze: | MEDLINE |
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